摘要
紫杉醇是近40年从红豆杉属植物中发现的最著名的天然抗肿瘤药物,在过去30年多年间紫杉醇因其独特的结构、新颖的作用机制和显著的抗癌活性成为化学家、药理学家和生物学家的研究热点。本文对紫杉醇构效关系的研究进行了总结,提供参考文献85篇。
Taxol is the most famous anti-cancer natural drug discovered from the plants of genus Taxus during the past 40 years. Its unique mechanism of action, challenging structure, limited solubility and shortage have generated world wide interest in various areas, and the extensive chemical and biological studies have been carried out in the past 30 years. This paper summarized the research progress on structure-activity relationship of taxol and 85 papers were cited.
出处
《天然产物研究与开发》
CAS
CSCD
2009年第3期535-544,共10页
Natural Product Research and Development
基金
科技部863科研基金(2003AA2Z3527)
教育部及河北省留学回国人员科研基金课题
河北省自然科学基金(08B032)
关键词
红豆杉
紫杉醇
构效关系
Taxus
taxol
structure-activity relationship
