摘要
目的探讨抗环瓜氨酸肽(CCP)抗体、类风湿因子(RF)、抗Sa抗体检测对类风湿关节炎的临床意义。方法对72例RA患者组,115例自身免疫性疾病组和102例正常对照组人群血清进行同时测定RF(速率散射比浊法)、抗CCP抗体(ELISA法)和抗Sa抗体(免疫印迹法),并对三者之间检测的一致性以及与其他临床指标的关系进行了分析。结果RF、抗CCP抗体和抗Sa抗体对RA的敏感性分别为83.3%、80.6%和33.3%,特异性分别为83.4%、97.2%和98.6%。三种指标两两联合检测对RA的诊断都具有较好的特异性,而敏感性以抗CCP抗体+RF最高(77.8%)。结论抗CCP抗体和抗Sa抗体均是RA特异性血清学指标,但两者与RF可相互补充,选择适当的指标联合检测有助于RA的早期诊断。
Objective To explore the clinical significance of anti- cyclic citrullinated peptide （CCP） antibody, rheumatoid factor （RF）, and anti-Sa antibody in diagnosis of rheumatoid arthritis （RA）. Methods RF was measured by rate nephelometry method, anti- CCP antibody was deiected by ELISA, and anti - Sa antibody was detected by immunoblotting testing in 72 patients with RA, 115 patients with autoimmune diseases, and 102 healthy controls. The consistency of their clinical significance and other indexes were intercompared and analyzed. Results in RA patients, the sensitivities of RF, anti -COP and anti- Sa were 83.3 %, 80.6 %, and 33.3 %, respectively; the specificities of them were 83.4 %, 97.2 %, and 98.6%, respectively. The specificity of combination examinations among them was higher, yet the sensitivity of combination between RF and anti - COP was the highest （77.8 % ）. Conclusions Anti - COP antibody and anti - Sa antibody are specific serological markers for RA, to associate result of anti- COP and anti - Sa with RF can be helpful for diagnosis of early RA.
出处
《实用预防医学》
CAS
2009年第4期1212-1214,共3页
Practical Preventive Medicine
关键词
抗CCP抗体
抗SA抗体
类风湿因子
类风湿关节炎
Anti - cyclic citrullinated peptide
Anti - Sa antibody
Rheumatoid factor
Rheumatoid arthritis
