摘要
综述了猪瘟病毒引起的机体免疫抑制因素主要包括损伤免疫器官、诱导淋巴细胞凋亡、引起囊膜糖蛋白E2变异、抑制I型干扰素产生、诱发白细胞减少和引起树突状细胞无应答。从而干扰抗原的递呈和抑制免疫抗体的产生,引起机体免疫抑制。
This article reviewed the immune suppression of classical swine fever virus mainly by means of damaging immune organs, inducing lymphocyte apoptosis, causing the variation of the envelope glycoprotein E2, inhibittiug the ＇production of Type Ⅰ interferon, inducing decrease of the leucocyte number and no response of dendritic cells. These factors interfered antigen presentation and inhibitted the production of immune antibody, thus caused immune suppression.
出处
《湖北农业科学》
北大核心
2009年第6期1519-1522,共4页
Hubei Agricultural Sciences
基金
国家科技支撑计划项目(2006BAD06A11
2006BAD06A17)
关键词
免疫抑制性
免疫应答
猪瘟病毒
immune suppression
immune response
classical swine fever virus
