摘要
目的探讨APACHEⅡ评分大于23的重症MODS患者血清VCAM-1、TNF-α等炎症因子之间及其与APACHE评分之间的关系,为临床判断患者预后、寻求有效的治疗方法提供依据。方法收集APACHEⅡ评分大于23的重症MODS患者血清,用ELISA的方法检测患者血清VCAM-1、TNF-α水平,并对患者行APACHEⅡ评分。结果1重症MODS患者血清VCAM-1及TNF-α均明显升高,而且二者明显正相关关系（r=0.395,P=0.012）。2VCAM-1及TNF-α与APACHEⅡ评分明显相关,尤以VCAM-1为著（r分别为0.526,0.227,P均小于0.05）。结论内皮细胞的损伤可能是导致MODS晚期炎症因子增高的重要原因;内皮细胞的损伤参与了MODS的发生发展;VCAM-1可作为评价重症MODS患者严重程度的指标。
Objectiive To explore the relationship among the level of VCAM-1 and TNF-α and APACHE Ⅱ score in severe MODS patients whose APACHE Ⅱ score was more than 23. Methods VCAM-1 and TNF- α level were detected with ELISA method, and the APACHE Ⅱ score of patients were counted up. Results The level of VCAM-1 and TNF-α of severe MODS patients were significantly raised, and has significantly positive correlation （r = 0.395,P= 0.012）. The level ofVCAM-1, TNF-α and APACHE Ⅱ score were significantly correlated, particularly VCAM-1 （r was 0.227 and 0.526 respectively, P〈0.05）.Conclusions VCAM-1 can be used as a severity index of patients with MODS.
出处
《国际医药卫生导报》
2009年第11期15-17,共3页
International Medicine and Health Guidance News
基金
广东省卫生厅医学科学技术研究基金项目（A2007642）
关键词
多脏器功能不全综合征
内皮细胞
炎症介质
Multiple organ dysfunction system
Endothelial cell
Inflammatory mediators
