摘要
目的:观察三维适形放射治疗(three dimensional-conformal radiotherapy,3DCRT)同步长春瑞滨与奈达铂化疗治疗局部晚期非小细胞肺癌的近期疗效及不良反应。方法:96例局部晚期非小细胞肺癌患者随机分为两组。同步组三维适形放射治疗联合长春瑞滨、奈达铂同步化疗组和单纯3DCRT组单纯三维适形放射治疗组,每组48例。按世界卫生组织(WHO)疗效及毒性标准来评价近期疗效和治疗毒性。结果:同步组有效率为83.3%(40/48),其中完全缓解(CR)为15.5(9/48)部分缓解(PR)为64.6(31/48);单纯3DCRT组有效率为58.6%,其中CR为12.5(6/48),PR为47.9(23/48)。同步组近期疗效明显好于单纯3DCRT组(P<0.05)。不良反应主要为1～2级放射性食管炎、放射性肺炎、胃肠道反应和1～3级白细胞减少;同步组高于单纯3DCRT组,两组比较差异无统计学意义(P>0.05)。结论:同步放化疗(3DCRT加长春瑞滨与奈达铂)治疗局部晚期非小细胞肺癌可以提高局部控制率,延长生存时间,不良反应率较低。
Objective：To evaluate the efficacy and safety of vinorelbine plus nedaplatin chemotherapy with concurrent three dimensional-conformal radiotherapy（3DCRT） in patients with locally advanced non-small cell lung cancer （NSCLC）. Methods：A total of 96 patients with locally advanced lung cancer were randomly divided into the two group,48 patients in the concument group were treated with vinorelbine plus vedaplatin chemotherapy with concurrent 3DCRT, while 48 patients in the 3DCRT group alone. Results： The response rate （CR ＋ PR） of the concurrent group and 3DCRT group alone were 83.3 % and 58.6%,respectively（P〈0. 05）. There was no significant differences on acute complications or specific sequelae between the two groups. Grade 1 to 2 acute radiation pneumonia acute radiation esophagitis and grade 1 to 3 leukocytopenia and gastrointestinal toxicity were similar btween the two groups. Conclusion：3DCRT combined with concurrent vinocetaxel plus nedaplatin chemotherapy is well tolerated and can improve the quality of life in most patients with locally advanced NSCLC.
出处
《中国临床医学》
2009年第3期359-361,共3页
Chinese Journal of Clinical Medicine
关键词
三维适形放疗
化疗
长春瑞滨
奈达铂
非小细胞肺癌
Three dimensional-conformal radiotherapy
Chemotherapy
Vinorelbine
Nedaplatin
Non-small cell lung cancer
