摘要
目的分析不同病理类型肺癌的CT灌注成像及其临床应用价值。方法采用GE64层VCT灌注成像技术,电影模式(层厚2.5-5mm/8层),总扫描时间40s,CT Perfusion 3分析软件,回顾性分析60例(腺癌35例,鳞癌11例,小细胞癌8例,转移癌6例),体积3.56～115.68cm^3肺癌的血流量(BF)、血容量(BV)、平均通过时间(MTT)、表面通透性(PS)、拟合时间-密度曲线(TDC)和肿瘤最高增强值(PE);依据肿瘤大小和病理类型的不同进行比较。结果主动脉第一时相为14～28s,平均19.8s。肿瘤的BV值、BF值为鳞癌>转移癌>腺癌>小细胞癌,其差异有统计学意义(P<0.05),MTT值和PS值的差异无统计学意义(P>0.05)。肿瘤平扫CT值比较,转移癌与其他组织类型差异性均有统计学意义(P<0.05);肿瘤最高增强值(PE)比较,除鳞癌与腺癌外,其他组之间差异性均有统计学意义(P<0.05)。大的肿瘤(体积>50cm^3)与小的肿瘤(体积<50cm^3)灌注值比较,其差异没有统计学意义(P<0.05)。肺癌的拟合时间-密度曲线和主动脉的关系密切,峰值在主动脉峰值区域或稍后,A型8例,B型52例,其中6例转移癌中A型曲线有4例,占50%。结论肺癌的灌注值与肿瘤大小无关,BV值、BF值与肿瘤的组织学类型有关;转移癌的TDC多表现为A型。
Objective To evaluate the characteristics of 64-multidetector-row CT perfusion imaging in lung cancer. Methods 64-multidetector-row CT perfusion was performed in 60 patients with lung cancer （adenocarcinoma in 35 cases, squamous cell carcinoma in 11 cases, small cell carcinoma in 8 cases, metastatic carcinoma in 6 cases）. The volume of tumors was 3.56-115.68cm^3. The parameters of CT perfusion were compared by pathologic types and volume of tumors, including blood flow （BF）, blood volume （BV）, mean transit time （MTT）, permeability surface （PS）, time density curve （TDC） and peak enhancement （PE）. GE VCT 64-multidetector-row CT was used in 60 cases, with cine mode of 2.5-5mm/8 slices. Scan time was 40 second. Analyzing software was CT perfusion-3. Results The first-phase of contrast medium flew through aorta Were 14-28s （mean value was 19.8s）. There were significant differences of BV and BF value among＇ pathologic types of lung cancer, and the outcome was as follow： squamous cell carcinoma〉 metastatic carcinoma〉 adenocarcinoma〉 small cell carcinoma. There were no statistical significances of MTT and PS values among different pathologic types.CT value of tumors in plain scan in metastatic carcinoma was significantly greater than in other pathologic types. There were significant differences of PE value in small cell carcinoma and metastatic carcinoma. No statistically differences between different volumes of tumors with regard to the parameters of perfusion imaging. The peak time of TDC located in the area of aorta peak time, of which 8 cases with type A and 52 cases with types B, and 4 cases （4/6,50%）of metastatic carcinoma with types A. Conclusion There is correlation between BV value, BF value and pathologic types, but no significant correlation of different volume of tumors. TDC of metastatic carcinoma mainly present as type A.
出处
《影像诊断与介入放射学》
2009年第3期131-134,共4页
Diagnostic Imaging & Interventional Radiology
关键词
肺癌
体层摄影术
X线计算机
灌注成像
Lung cancer
Perfusion imaging
Tomography, X-ray computed
