摘要
目的探讨痛风颗粒治疗急性痛风性关节炎的作用机制。方法复制大鼠尿酸钠关节炎模型,观察痛风颗粒对大鼠右踝关节肿胀度、LP-PLA2值的影响。结果痛风颗粒对大鼠踝关节肿胀有明显的抑制作用,能显著降低大鼠血清LP-PLA2值,与秋水仙碱作用相近。结论痛风颗粒对急性痛风性关节炎具有治疗作用,其作用机制与抑制血清LP-PLA2的产生有关。
Objective： To study the mechanism of gouty granule on the treatment of acute gouty arthritis. Methods： The rats＇ models of sodium urate arthritis were mode, and the effects of gouty granule on LP-PLA2 value and swollen right ankle joint degrees of rat model were observed. Results： Gouty granule inhibited the ankle swelling of rats＇ models obviously, and reduced serum value of LP-PLA2 significantly. It was no significant difference with eolchicine group. Conclusion： Gouty granule has a the rapeutie effect in the treatment of acute gouty arthritis, and its mechanism may be inhibiting serum LP-PLA2 production.
出处
《中国中医急症》
2009年第7期1133-1134,共2页
Journal of Emergency in Traditional Chinese Medicine
基金
湖北省武汉市卫生局科研项目(No.200247)
关键词
痛风颗粒
尿酸钠关节炎模型
实验研究
大鼠
Gouty granule
Models of sodium urate arthritis
Experimental research
Rats
