摘要
目的:探讨脾脏指突状树突细胞肉瘤的诊断要点及其鉴别诊断。方法:对1例脾脏指突状树突细胞肉瘤进行组织病理学、免疫组化染色,并随访。结果:肿瘤原发于脾脏并累及肝脏,于确诊4月后死亡。镜检:肿瘤组织呈席纹状、旋涡状或杂乱排列,瘤细胞卵圆形、梭形,胞质少,核卵圆形或短梭形,染色质少,部分有核仁,分裂象多见。瘤细胞S-100、CD68散在阳性、Vimentin和LCA阳性;CD21、CD35、CD1a等均阴性。结论:指突状树突细胞肉瘤极为罕见,容易漏诊和误诊,熟悉其临床病理特点,依靠免疫组化和电镜检查可确诊。
Objective：To investigate the clinical pathological features and differential diagnosis of spleen interdigiating dendritic cell sarcoma（IDCS）. Methods： A case of IDCS of spleen was analyzed by light microscopy, immunohistochemical staining. Results： The tumor of IDCS located in spleen, and infiltrated liver, died after 4 months. Microscopically, the normal architectures were affaced by proliferation of medium to large spindle - shaped cells with fascicular, storiform or whorled patterns and with less cytoplasm. The mitotic figures was easily found. Immunohistochemi cal studies showed that the tumor ceils was positive for S - 100,CD68,Vinentin and LCA,but negative for CD21, CD35, CD1a, SMA and Desmin. Conclusion： As a rare tumor, IDCS is often neglected or misdiagnosed. Immunohistochemistry and electron microscopy examinations may contribute to the differential diagnosis of IDCS.
出处
《现代肿瘤医学》
CAS
2009年第7期1333-1335,共3页
Journal of Modern Oncology
关键词
指突状树突细胞肉瘤
脾脏
肝脏
免疫组化
interdigitating dendritic cell sarcoma
spleen
liver
immunohistochemistry
