摘要
目的:探讨早期应用普伐他汀对血脂正常的心绞痛患者血浆vWF水平和血管内皮功能的影响。方法:将58例血脂正常的不稳定心绞痛患者随机分为普伐他汀组(n=32,除常规治疗外加服普伐他汀)和对照组(n=26,仅常规治疗),于治疗前、治疗后1周和8周分别检测血浆vWF水平和血脂。每组选择15例于治疗前和治疗后8周行肱动脉血管内皮功能测定。记录8周内心脏缺血相关事件。结果:治疗1周后,对照组vWF水平明显升高(P<0.05),普伐他汀组vWF水平也升高,但没有统计学意义(P>0.05);治疗8周后,普伐他汀组vWF水平与治疗前相比明显降低(P<0.05);普伐他汀组FMD较对照组明显升高(P<0.05)。普伐他汀组TC、TG较治疗前均明显降低(P<0.05),HDL水平较治疗前均明显升高(P<0.05)。普伐他汀组心脏缺血相关事件虽较对照组有所下降,但无统计学意义(9.4%比15.4%,P=0.058)。结论:血脂正常的不稳定心绞痛患者早期应用普伐他汀可抑制血浆vWF的升高,改善血管内皮功能。
Objective： To investigate the effects of early administration of pravastatin treatment on plasma level ofvWF and function of vascular endothelium in normocholesterolemic patients with unstable angina. Methods： 58 patients with unstable angina were di- vided randomly into two groups （control group, n=26; pravastatin group, n=32）. Blood samples were examined at admission and 1, 8 weeks after the therapy of pravastatin. 15 patients from each group were chosen for measuring the function of vascular endothelium by ultrasound before and 8 weeks after the therapy. Ischemia events of heart were followed up at the same time. Results： After 1 week of treatment, a significant increase ofvWF was found in the control group （P〈0.05）, but not in pravastatin group. At 8 weeks after admission, plasma level ofvWF was significantly lower than at baseline in pravastatin group （P〈0.05）; a significant decrease ofTC, TG and a significant increase of HDL were found in the pravastatin group; FMD in pravastatin group was significantly higher than control group （P〈0.05）. There was no significant difference in the ischemia events of heart between the two groups （P=0.058）. Conclusions： In normoc- holesterolemic patients with unstable angina, the early administration of pravastatin significantly affects plasma level of vWF and improves the function of vascular endothelium.
出处
《现代生物医学进展》
CAS
2009年第12期2284-2286,2321,共4页
Progress in Modern Biomedicine
