摘要
气道黏液主要由气道上皮细胞及黏膜下腺体分泌，通过纤毛摆动将病原体、理化物质等排出气道，而气道黏液的弹性主要由相对分子质量高的黏蛋白决定。由于黏蛋白的过度分泌是许多慢性气道炎症疾病的病理生理特点，所以许多关于调剂气道黏液的药物机制都主要集中在调节黏液蛋白分泌，但这些药物大多仍停留在动物实验阶段和前期临床阶段。
Mucus secreted mainly by epithelial goblet cells and submucosal glands covering the respiratory tract plays an important role in the protection from external aggressions, such as solid particles, pathogens and chemical agents by mucociliary clearance. The viscoelastic properties of mucus are mainly determined by the presence of high molecular weight mucins. Mucus hypersecretion in the airway is the common pathophyisological characteristic of many chronic airway inflammation disease. A good number of drugs regulating hypersecretion of mucus have improved in recent years. There have been newly-developed drugs,many of which have still been on stages of animal tests or clinic tests.
出处
《国际呼吸杂志》
2009年第13期801-804,共4页
International Journal of Respiration
