摘要
聚氨酯侧链接枝末端含有大量羟基且具有良好生物相容性的脂肪族聚酯树枝状分子,在引入大量反应官能团的同时增加分子间空间间隔,为生物活性分子的接枝提供一种性能优异的中间材料。通过1H-NMR、DSC、接触角及表面分析等测试方法表征聚氨酯树枝化前后结构及性能的改变。结果显示,多羟基树枝化线形聚氨酯的氢键化程度大大提高,结晶性能降低,亲水性及表面粗糙度增加。细胞培养试验证明,该材料具有很好的细胞相容性,为其在生物医学上的应用奠定了良好的基础。
Novel polyhydric dendronized linear polyurethanes which can be used as intermediate materials for conjugation of bioactive molecules were successively synthesized through covalently immobilization of polyester dendrons at the side chains followed by a deprotection process of the acetonide groups. This method not only introduces lots of reactive groups but also grafts spacers between polymer chains. The structure of the polyester dendron immobilized polyurethane was characterized by ^1 H-NMR method. DSC analysis showed declined degree of crystallization in contrast with the unmodified polyurethane. The results of water contact angle test revealed improved hydrophilicity after modification. The formation of rough topographical features could be clearly seen on SEM photos. Meanwhile, endothelial cells culture showed improved cytocompatibility of dendronized polyurethanes than unmodified samples, which appears to be promising as a biocompatible material, consequently, as a potential carrier for biomacromolecules conjugation.
出处
《化工新型材料》
CAS
CSCD
北大核心
2009年第6期30-33,共4页
New Chemical Materials
基金
国家863项目(2007AA02Z450)
