摘要
目的:探讨胰岛素抵抗在急性脑梗死形成中的作用以及观察复元醒脑汤对急性脑梗死患者胰岛素抵抗的干预作用。方法:选择112例急性脑梗死患者,随机分为治疗组和对照组,各56例。对照组采用西医常规治疗,治疗组在西医常规治疗的基础上口服复元醒脑汤。两组均以14天为1个疗程,观察两组总有效率及治疗前后空腹血糖(FPG)、空腹血清胰岛素(FINS)、胰岛素敏感指数(ISI)的变化。并与正常组30例对照。结果:脑梗死患者治疗前空腹血糖(FPG)、空腹血清胰岛素(FINS)明显偏高,胰岛素敏感指数(ISI)明显偏低,与正常组比较,差异有显著性意义(P<0.01)。治疗组和对照组总有效率分别为91.1%、75%,组间疗效比较,差异有统计学意义(P<0.05)。治疗组和对照组FPG、FINS、ISI治疗前后自身比较,差异均有统计学意义(P<0.05);治疗组和对照组治疗后组间比较,ISI差异有统计学意义(P<0.05)。结论:胰岛素抵抗在急性脑梗死形成中起重要作用。复元醒脑汤结合西医常规治疗能明显提高急性脑梗死的临床疗效,同时可显著改善胰岛素抵抗。其治疗急性脑梗死的作用机制可能与改善胰岛素抵抗有关。
Objective：To investigate the effect of insulin resistance on the formation of acute cerebral infarction and to study intervention with FuYuan Xingnao decoction on insulin resistance in patients with acute cerebral infarction. Methods：One hundred and twelve patients of acute cerebral infarction were randomly divided into treatment group（ n = 56） and western medicine control group （ n = 56）. Conventional therapy of western medicine was applied for the western medicine control group, while Fuyuan Xingnao Decoction in addition to conventional therapy was applied for the treatment group for 14 days. Total effective rate was evaluated and fasting blood glucose （ FPG）, fasting insulin of blood serum （ FINS）, and insulin sensitivity index（ISI） were detected before and after treatment in each group. Thirty healthy subjects served as normal control group. Results： FPG and FINS in patients of acute cerebral infarction before treatment were obviously higher and ISI was distinctly lower with statistical significant difference compared with that of the normal control group（ P 〈 0.01 ）. The total effective rate were 91.1% and 75% respectively in the treatment and western medicine control groups with statistical significant difference （P 〈0.05）. Statistical significant differences were noted in the level of FPG, FINS and ISI before and after treatment in the treatment group or western medicine control group（ P 〈 0.05 ） and in the level of ISI between the treatment and western medicine control groups after treatment （ P 〈 0.05 ）. Conclusion： Insulin resistance plays an important role in the formation of acute cerebral infarction. Fuyuan Xingnao decoction combined with conventional treatment of western medicine may raise the clinical therapeutic effect on treating acute cerebral infarction and attenuate insulin resistance. Fuyuan Xingnao decoction may treat acute cerebral infarction by attenuating insulin resistance.
出处
《浙江中西医结合杂志》
2009年第7期400-402,共3页
Zhejiang Journal of Integrated Traditional Chinese and Western Medicine
基金
国家"十一五"科技支撑计划资助项目(No.2006BAI04A02)
关键词
急性脑梗死
胰岛素抵抗
复元醒脑汤
cerebral infarction Fuyuan Xingnao decoction insulin resistance
