摘要
目的了解浙江省湖州地区孕妇乙型肝炎病毒（HBV）感染程度和宫内感染的关系。方法采用时间分辨免疫荧光分析法测定乙型肝炎标志物（HBVM），荧光定量PCR技术测定HBV．DNA。结果1262例孕妇HBVM感染阳性率：HBsAg、HBsAb、HBeAg、HBeAb、HBcAb总体阳性率分别为2．6％（33／1262），38．2％（482／1262），0．9％（11／1262），22．6％（285／1262）和23．1％（291／1262）。33例血清HBsAg阳性孕妇中，11例HBeAg阳性者HBV—DNA多为高载量，宫内感染率是6／11；22例HBeAg阴性者HBV—DNA多为低载量，宫内感染率是2／22；两者比较差异有统计学意义（P〈0．01）。总计HBsAg阳性孕妇宫内感染率是24．2％（8／33）。结论浙江省湖州地区孕妇乙型肝炎病毒感染率较低。孕妇血清HBeAg阳性和HBV—DNA含量高，易发生宫内感染。
Objective To investigate the relationship between the hepatitis B virus （HBV） infection in pregnant women and intrauterine infection in local region. Methods The markers of hepatitis B （HBVM） were determined by time-resolved fluoroimmunoassay and HBV-DNA were determined by FQ-PCR. Results A total of 1262 pregnant women were examined the HBVM, 2.6%, 38.2%, 0.9%, 22.6%, 23.1% subjects were identified HBsAg, HBsAb, HBeAg, HBeAb, HBeAb positive respectively. In 33 cases of serum HBsAg-positive pregnant women, HBV-DNA were observed in most of 11 cases of pregnant women with HBeAg-positive and intrauterine infection rates were 6/11. In contrast, 22 cases of pregnant women with HBeAg negative, HBV-DNA were detected lowly-loaded and intrauterine infection rates were 2/22 （ P 〈 0.01 ）. Intrauterine infection rates of HBV in pregnant women with HBsAg-positive were 24.2% （8/33）.Conclusion HBV infective rates in pregnant women in the local region were low. Pregnant women with serum HBeAg positive and HBV-DNA high-loaded were prone to intrauterine infection.
出处
《中华实验和临床病毒学杂志》
CAS
CSCD
北大核心
2009年第3期235-237,共3页
Chinese Journal of Experimental and Clinical Virology
关键词
肝炎病毒
乙型
生物学标记
疾病传播
垂直
Hepatitis B virus
Biological markers
Diseases transmission, vertical
