摘要
从邻甲代烯丙氧基苯酚反应合成呋喃酚的反应历程出发,建立了邻甲代烯丙氧基苯酚合成呋喃酚的动力学模型.在数值模拟,仿真优化以及实验室工作的基础上,对环合反应的工艺操作条件进行了优化,即反应温度152℃,邻甲代烯丙氧基苯酚的初始质量分数为32%,催化剂质量分数为邻甲代烯丙氧基苯酚质量的3.0%,反应时间10 h.在此工艺条件下,反应的转化率可以达到96%以上,收率大于75%.同时环合动力学模型的建立也为呋喃酚的工业生产装置的放大与设计提供了理论基础.
Starting from the routes of rearrangement reaction and cyclization reaction, the kinetic model for synthesizing benzofuranol from o-methallyloxyphenol was proposed. Based on numerical simulation, simulation optimization and laboratory experiment, the optimized conditions of cyclization reaction obtained were the reaction temperature of 152 ℃, the initial concentration of o-methallyloxyphenol of 32 %, the catalyst concentration of 3.0 %, and the reaction time of 10h. Under the optimized conditions, the conversion was above 96 %, and the yield reached 75 %. The cyclization model equations will provide some theoretical basis for the industrial scale-up of benzofuranol production.
出处
《湖南大学学报（自然科学版）》
EI
CAS
CSCD
北大核心
2009年第6期45-49,共5页
Journal of Hunan University:Natural Sciences
基金
国家863计划资助项目(2006AA03Z0460)
湖南省自然科学基金资助项目(05JJ30025)
