摘要
目的:回顾性总结41例剖宫产瘢痕妊娠(cesarean scar pregnancy,CSP)病例临床资料,探讨利用平阳霉素(PYM)和甲氨蝶呤(MTX)联合局部注射新方法对于剖宫产瘢痕妊娠的治疗效果。方法:收集2003年-2009年2月我院妇科收治的41例早期剖宫产瘢痕妊娠病例,20例使用单独甲氨蝶呤局部注射,21例使用平阳霉素和甲氨蝶呤联合注射。比较注射后血β-HCG下降动力学曲线,孕囊包块大小,子宫局部血流量等情况。结果:2组都能成功治疗剖宫产瘢痕妊娠,联合用药在改善β-HCG下降动力学曲线,加快孕囊包块的吸收,降低子宫局部血流量方面均优于单独使用MTX。结论:对早期剖宫产瘢痕妊娠的患者进行药物治疗,首次使用平阳霉素(PYM)和甲氨蝶呤(MTX)联合用药,对加快β-hCG水平的下降,降低大出血、子宫破裂以及降低持续性剖宫产子宫瘢痕妊娠的风险有显著效果。
OBJECTIVE To analyzed the clinic data of 41 cesarean scar pregnancy cases,and observe results of a new method for treatment of the CSP using combined Pingyangmycin and Pingyangmycin, and campared with only using MTX. METHODS 20 of 41 cases were treated with MTX only, and the other 21 were injected with combination of PYM and MTX. The success rates, and time to resolution of serum β-hCG and the CSP mass were compared between the two groups. RESULTS Both therapies could treat the majority of CSP patients successfully, but the combined therapy resulted in a shorter time of therapy and indicated a more favorable effect. CONCLUSION It might be the first time to use combined PYM and MTX treatment for CSP, with a better result compared with using MTX along, this test can improve the treatment of CSP, and decrease the risk of the desease.
出处
《中国医院药学杂志》
CAS
CSCD
北大核心
2009年第12期1015-1018,共4页
Chinese Journal of Hospital Pharmacy
