摘要
目的探讨膀胱尿路上皮癌与Fas介导的血T淋巴细胞凋亡的关系。方法应用流式细胞仪检测52例膀胱癌患者和37例健康对照者外周血CD4Fas、CD8Fas阳性T细胞。结果膀胱癌患者外周血CD4、CD8Fas阳性T细胞分别为（20．74±9．02）％、（7．51±5．93）％，对照组分别为（15．68±5．58）％、（4．27±3．08）％，肿瘤组较对照组明显增加（P〈0．01）。浸润组CD8Fas阳性T细胞数为（5．83±3．95）％，表浅组为（5．83±3．95）％，浸润组较表浅组明显降低（P〈0．05）。复发组CD4、CD8Fas阳性T细胞与初发组比较差异无统计学意义（P〉0．05）。结论血T淋巴细胞Fas表达的异常可能在膀胱癌的发生发展中起重要的作用。
Objective To investigate the relationship between the Fas expression in peripheral blood T cells and bladder transitional cell carcinoma （TCC）. Methods The Fas expression in peripheral blood T cells of 52 patients with TCC and 37 healthy people was detected by flowcytometry. The Fas-positive rate was compared by t test between two designed groups. Results The Fas expression in CD4^± [ （20. 74 ± 9. 02）% ] and CD8^±[ （7. 51 ±5. 93 ）% ] was increased in TCC patients as compared with controls （P 〈 0. O1 ）. Fas-positive CD8^± cells were reduced in invasive TCC as compared with superficial TCC [ （ 5.83 ± 3.95 ） % vs （ 5.83 ± 3.95 ） %, P 〈 0. 05 ], but there was no difference between primary and recurrent cases （ P 〉 0. 05 ）. Conclusion The abnormal Fas expression in peripheral blood T cells may play an important role in the development and progression of TCC.
出处
《中华实验外科杂志》
CAS
CSCD
北大核心
2009年第7期920-921,共2页
Chinese Journal of Experimental Surgery
