摘要
对132例光线性角化病进行临床及组织病理分析。男64例,女68例,平均年龄(62.26±14.10)岁,皮损发生于头面部及颈部,临床表现多为肤色或淡褐色角化性斑丘疹,上覆粘着性鳞屑,皮损周围皮肤可见萎缩、毛细血管扩张或淡黄色斑等慢性光损伤的表现。皮损组织病理特点包括角化过度、角化不全,基底层甚至棘层不典型角质形成细胞增生,细胞排列紊乱,基底层不典型角质形成细胞呈芽蕾状伸入真皮乳头层,真皮浅层嗜碱性变,炎性细胞浸润。组织病理分型主要是肥厚型和萎缩型。
The clinicopathological features of 132 patients with actinic keratosis were analysed, including 64 males and 68 females with a mean age of （62.26±14.10） years. The lesions were located on the head, face and neck of the patients. Most lesions were described as skin-colored or light brown keratotic maculopapules, covered with adherent scales and surrounded by chronic actinic damage such as atrophy, telangiectasias and yellowish discoloration. Histopathology showed hyperkeratosis, parakeratosis, and proliferation of atypical keratinocytes in basal layer and prickle cell layer, with disarrangement of epidermal polarity. The atypical keratinocytes slightly protruded into the papillary dermis as small round buds. The dermis often showed basophilic changes with a mild inflammatory infiltration. The histologic variants were mainly hypertrophic actinic keratosis and atrophic actinic keratosis.
出处
《临床皮肤科杂志》
CAS
CSCD
北大核心
2009年第7期423-426,共4页
Journal of Clinical Dermatology
