摘要
目的探讨肠外+肠内营养(PN+EN)与完全肠外营养(TPN)支持,对肾移植术后重症肺部感染患者免疫功能的影响。方法将2004年6月至2008年9月20例肾移植术后重症肺部感染患者随机分为对照组、观察组,每组10例,观察组接受PN+EN,对照组接受TPN,两组等氮、等热量供给;于治疗前、后检测血浆总蛋白、清蛋白、血红蛋白浓度,外周血IgA、IgG、IgM、淋巴细胞总数TLC、CD4/CD8比值。结果与对照组相比,观察组TLC、CD4/CD8比值和IgG有所增高(P<0.05);两组间总蛋白和清蛋白及组内营养支持前、后的变化差异不明显(P>0.05)。结论PN+EN较TPN更能改善肾移植术后重症肺部感染患者的免疫功能。
Objective To study the effect of parenteral plus enteral nutrition （PN＋EN） and total parenteral nutrition （TPN） support on the postoperative immune function in renal recipients with severe pulmonary infection. Methods Twenty renal recipients with severe postoperative pulmonary infection were randomly assigned into two equal groups to receive PN＋EN or standard TPN, both supplied with equal nitrogen and calorie. The plasma levels of total protein, albumin, hemoglobin and peripheral blood IgA, IgG, IgM, total lymphocyte count, and CD4/CD8 ratio were measured before and after the treatment. Results The total lymphocyte count, CD4/CD8 ratio and IgG were significantly increased in patients receiving PN＋EN as compared with those in TPN group （P〈0.05）. In both of the groups, the total protein and albumin levels underwent no significant changes after the nutritional support （P〉0.05）. Conclusion PN＋EN can better improve the immune fimction than TPN in renal recipients with severe pulmonary infection.
出处
《南方医科大学学报》
CAS
CSCD
北大核心
2009年第6期1159-1162,共4页
Journal of Southern Medical University
基金
宁夏回族自治区自然科学基金资助课题(NZ0663)
关键词
肾移植
重症肺部感染
营养支持
免疫功能
renal transplantation
severe pulmonary infection
nutritional support
immune function
