摘要
目的探讨发作性运动诱发性舞蹈样手足徐动症(PKC)的临床特点及对药物治疗的反应。方法对52例PKC患者临床表现、实验室资料及治疗经过进行分析。结果52例患者发病年龄6～21岁,病程2个月～24年,79%为男性。临床表现为发作性一侧或双侧肢体、头面部、躯干不自主运动,诱发因素为突然运动、紧张、惊吓。持续时间一般为数秒。发作时无意识障碍,发作间歇期完全正常。对抗癫药物有良好反应。结论PKC是一种由运动诱发的、短暂的发作性局部或全身不随意运动,癫药治疗效果好。
Objective To study the clinical characteristics, electrophysiological manifestations and pathogenesis of paroxysmal kinesigenic choreoathetosis（PKC）. Methods The clinical characteristics of 52 patients with PKC during 2000 to 2008 were analyzed, including the clinical manifestation, the factors inducing the attacks, duration of episode, therapeutic response etc. Etiologic studied included EEG,24 hours EEG monitoring,brain CT/MRI. Results Of 52 patients with PKC,the age of onset ranged from 6 to 21 years old, the history of PKC ranged from 2 months to 24 years. Seventynine percent of the patients were male. The episodes of all the cases were induced by sudden movement. The duration of the attack was brief, usually lasting only seconds. The attacks in all the cases were periodic involuntary movements of one side or both sides of the limbs, trunks, face,and were often associated with dystonic,choreic, ballistic or athetoid movements without loss of consciousness. All laboratory tests showed no abnormality except for 4 patients had ahnormal EEG findings and 2 patients had abnormal CT findings. All patients responded well to antiepileptic drugs. Conclusion PKC is one kind of paroxysmal dyskinesias. PKC is characterized by short paroxysmal of focal or generalized involuntary movement induced by sudden movement. PKC is known to be a treatable disorder. Antiepileptic drugs are effective in the treatment of this disease.
出处
《中国实用神经疾病杂志》
2009年第10期24-27,共4页
Chinese Journal of Practical Nervous Diseases
