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刺激强度对黑质DA能神经元伤害性反应的影响

INFLUENCE OF STIMULATION INTENSITY ON THE NOCICEPTIVE RESPONSES OF NIGRAL DOPAMINERGIC NEURONS IN THE RAT
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摘要 本研究用细胞外记录方法研究大鼠黑质多巴胺能神经元伤害性反应的特点。共记录了194个多巴胺能神经元。其中,大多数神经元(78%)可被尾部强电刺激(15mA,1.0ms)所抑制,15%被兴奋。兴奋和抑制反应均依赖于刺激强度。当刺激强度变化于0~20mA时,伤害性反应强度与刺激强度的对数显著相关。来自不同部位的刺激可会聚于同一神经元。反应潜伏期和阈值提示Aδ纤维参与伤害性信息传入黑质的过程。本文还讨论了多巴胺能神经元系统在痛觉机制中的作用。 The characteristics of nociceptive responses from presumed dopaminergic neurons in substantia nigra were investigated in the rat withextracellular recordings of single unit. 194 presumed dopaminergic neurons were recorded. A majority of these neurons (78%) could be inhibited by intensive electrical stimulation applied to the tail(15mA, 1.0ms)and 15% were excited. Both inhibitory ,and excitatory responses were intensity-dependent and correl- ated with the logarithm of the stimulation intensity, when the stimulatio n intensity varied from 0 to 20 mA. Nociceptive inputs from various parts of the body could converge on the same dopaminergic neuron. Both response latency and threshold indicated the participation of Aδ fiber in projecting nociceptive information to substantia nigra. The possible effect of nigral dopaminergic neurons in the pain process was also discussed in this paper.
出处 《锦州医学院学报》 1990年第2期84-89,共6页 Journal of Jinzhou Medical College
关键词 黑质 DA能神经元 伤寒性反应 刺激 substantia nigra nociception dopaminergic neuron antidromic stimulation
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  • 1孙德玉,王文琴,姜恩魁,高东明.家兔黑质内注射多巴胺对电针镇痛作用的影响[J]针刺研究,1985(01). 被引量:1
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