摘要
目的观察妊娠期糖尿病患者胰岛素抵抗的现象。方法40例妊娠期糖尿病(gestational diabetes melli-tus,GDM)患者、34例糖耐量试验正常的孕妇作对照组,测定空腹血糖(fasting serum glucose,FPG)、胰岛素(fasting in-sulin,FINS)、血脂,口服糖耐量试验(oral glucose tolerance test,OGTT)2h血糖(2hPG)、2h胰岛素(2hINS)。同时稳态模型(HOMA)计算胰岛素抵抗指数(HOMA-IR)。结果①与对照组相比:GDM组FPG、2hPG、FINS、2hINS、甘油三酯(triglyceride,TG)、低密度脂蛋白(low density lipoprotein cholesterol,LDL-C)明显高于对照组,差异有统计学意义;②GDM患者胰岛素抵抗指数明显高于对照组,差异有统计学意义。结论GDM患者存在明显的胰岛素抵抗及糖脂代谢紊乱。
Objective To investigate the phenomenon of insulin resistance in patients with gestational diabetes mellitus （GDM）. Methods Fasting plasma glucose （FPG）, fasting serum insulin （FINS）, lipid , 2h plasma glucose （2hPG） and 2h serum insulin （2hINS） during oral glucose tolerance test （OGTT） were determined in 40 GDM patients and 34 control subjects. The insulin resistance index （HOMA-IR） was calculated. Results （1） FPG, 2hPG, FINS, 2hINS, triglyeeride （TG）, low density lipoprotein cholesterol （LDL-C） were significantly higher in GDM patients than in control subjects. （2） HOMA-IR was significantly higher in GDM patients than in control subjects. Conclusion There is obvious insulin resistance and metabolic disorder in GDM patients.
出处
《华南国防医学杂志》
CAS
2009年第3期40-41,44,共3页
Military Medical Journal of South China
基金
广西壮族自治区卫生厅科研课题(Z2005165)
关键词
妊娠期糖尿病
胰岛素抵抗
代谢紊乱
Gestational diabetes mellitus
Insulin resistance
Metabolic disorder
