期刊文献+

滑膜成纤维细胞在类风湿关节炎中的作用 被引量:7

原文传递
导出
摘要 正常滑膜关节的滑膜只有1~2层细胞,而类风湿关节炎(rheumatoid arthritis,RA)由于滑膜细胞大量增生,滑膜明显增厚。滑膜细胞主要有巨噬细胞(又称A型滑膜细胞)和滑膜成纤维细胞(svnovial fibroblast,SF)(又称B型滑膜细胞)两类,此外,还有大量浸润的T淋巴细胞、B淋巴细胞和树突状细胞等。SF的生理功能主要是提供关节腔及周围软骨营养和润滑。
出处 《中华风湿病学杂志》 CAS CSCD 北大核心 2009年第6期412-414,共3页 Chinese Journal of Rheumatology
基金 国家自然科学基金(30672112) 全军医药卫生科研基金(06Q45) 上海市浦江人才计划(06PJJ4121)
  • 相关文献

参考文献15

  • 1Matsnmoto S,Muller-Ledner U,Gay RE,et al.Ultrastructural demonstration of apoptosis,Fas and Bcl-2 expression of rheumatoid synovial fibroblasts.J Rheumatol,1996,23:1345-1352. 被引量:1
  • 2Migita lL Miyashita T,Ishibashi H,et al.Suppressive effect of leflunomide metabolite (A77 1726) on metalloproteinase production in IL -I beta stimulated rheumatoid synovial fibroblasts.Clin Exp Immunol,2004,137:612-616. 被引量:1
  • 3Cha HS,Bosengren S,Boyle DL,et al.PUMA regulation and proapeptotic effects in fibroblast-like synoviocytes.Arthritis Rheum,2006,54:587-592. 被引量:1
  • 4Franz JlL Pap T,Hummel KM,et al.Expression of sentrin,a novel antiapoptotic molecule,at sites of synovial invasion in rheumatoid arthritis.Arthritis Rheum,2000,43:599-607. 被引量:1
  • 5Liu H,Huang Q,Shi B,et al.Regulation of Mcl-1 expression in rheumatoid arthritis synovial macrophages.Arthritis Rheum,2006,54:3174-3181. 被引量:1
  • 6Smith RS,Smith TJ,Blieden TM,et al.Fibroblasts as sentinel cells.Synthesis of chemokines and regulation of inflammation.Am J Pathol,1997,151:317-322. 被引量:1
  • 7Sakuma M,Hatsushika K,Koyama lL et al.TGF-β type I receptor kinase inhibitor down-regulates rheumatoid synoviocytes and prevents the arthritis induced by type Ⅱ collagen antibody.Int Immunol,2007,19:117-126. 被引量:1
  • 8DeBusk LM,Chen Y,Nishishita T,et al.Tie2 receptor tyresine kinase,a major mediator of tumor necrosis factor alpha-induced angiogenesis in rheumatoid arthritis.Arthritis Rheum,2003,48:2461-2471. 被引量:1
  • 9Hanyuda M,Kasama T,Isezaki T,et al.Activated leucocytes express and secrete macrophage inflammatory protein-lalpha upon interaction with synovial fibroblaats of rheumatoid arthritis via a beta2-integrin/ICAM-1 mechanism.Rheumatology (Oxford),2003,42:1390-1397. 被引量:1
  • 10Siegle I,Klein T,Backman JT,et al.Expression of cyclooxygenase 1 and cyelooxygenase 2 in human synovial tissue:differential elevation of cyclooxygenase 2 in inflammatory joint diseases.Arthritis Rheum,1998,41:122-129. 被引量:1

同被引文献68

引证文献7

二级引证文献31

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部