摘要
目的：建立非放射性彩色微球测定穿壁及分层单位心肌血流量的方法并检测其准确性。方法：应用非放射性彩色微球测定２０只猪冠状动脉狭窄前后穿壁及分层单位心肌血流量，并与超声血流计测值比较。结果：穿壁单位心肌血流量超声血流计与非放射性彩色微球测值呈高度线性相关（ｙ＝０．８２２ｘ＋０．１４３，ｒ＝０．９６３，Ｐ＜０．００１）；不同颜色非放射性彩色微球对同一时刻单位心肌血流量测值无显著差异（Ｐ＞０．０５）；非放射性彩色微球在冠状动脉狭窄前测得心内膜、心外膜下单位心肌血流量分别为１．４３±０．５３和１．２８±０．５４ｍｌ／（ｇｍｉｎ）（Ｐ＜０．０１）；狭窄后分别为０．６７±０．３１和０．８８±０．３２ｍｌ／（ｇｍｉｎ）（Ｐ＜０．０１）。狭窄后心内膜下比心外膜下单位心肌血流量下降幅度更为显著（Ｐ＜０．０１）。结论：非放射性彩色微球可准确测定穿壁及分层单位心肌血流量，可作为研究心肌灌注的一种新方法。
? Objective:This study was designed to develop a new method,colored microspheres(CM),for measuring myocardial blood flow,and to test the accuracy of CM for measuring transmural,subendocardial and subepicardial blood flow. Methods:An animal model of coronary stenosis was created in 20 pigs.Transmural,subendocardial and subepicardial blood flows were measured with CM,and transmural myocardial blood flow measured by CM was compared with that by ultrasonic flowmetry(TF). Results:There was a highly linear relationship between transmural myocardial blood flows measured by TF and CM(y=0.822x+0.143,r=0.963,p<0.001).Myocardial blood flow measured with various colored microspheres at the same experimental period was insignificantly different (p>0.05).The subendocardial and subepicardial blood flows measured with CM were 1.43±0.53 and 1.28±0.54 ml/(g·min) (p<0.01),respectively before coronary stenosis,and 067±031 and 0.88±0.32 ml/(g·min)(p<0.01),respectively,after coronary stenosis.The subendocardial blood flow after coronary stenosis was decreased more than the subepicardial one (p<0.01). Conclusion:CM can accurately measure the transmural,subendocardial and subepicardial blood flows so as to be a new method for studying myocardial perfusion.
出处
《中国循环杂志》
CSCD
北大核心
1998年第2期75-77,共3页
Chinese Circulation Journal
基金
福建省自然科学基金
