摘要
目的分别评估亚洲骨质疏松筛查工具（OSTA）及上海市绝经后妇女低骨量简易筛选方法（STLBMS）与上海市绝经后妇女骨密度及椎体骨折的关系,并比较两种筛选方法对骨质疏松和椎体骨折发生的预测能力。方法共入选988例绝经后妇女,有或无脊椎压缩性骨折各494例。两组均用双能X线吸收仪检测腰椎和股骨近端骨密度,并计算OSTA与STLBMS指数。结果两种筛选法均显示骨折组风险指数更高（P〈0.001）;在两组中分别比较两种筛选法,均显示STLBMS法的风险指数更高（P〈0.001）。OSTA与STLBMS指数与骨密度均正相关（r=0.336～0.562和r=0.383～0.570,P均〈0.001）;而两种筛选指数间呈显著正相关（r=0.974,P〈0.001）。以OSTA≤-1和STLBMS≤5为分界点,OSTA与STLBMS法诊断骨质疏松的工作曲线,曲线下面积（AUC）分别为0.73和0.74;在预测椎体骨折方面,OSTA与STLBMS法的AUC分别为0.55和0.57。结论OSTA和STLBMS筛选法均与骨密度呈显著正相关,也有助于椎体骨折的发现,两种方法对骨质疏松和椎体骨折发生的预测能力没有统计学差异,是理想的骨质疏松筛选工具。
Objective To estimate the relationship of the Osteoporosis Self-Assessment Tool for Asians （OSTA） and a simple screening tool for low bone mass of Shanghai （STLBMS） with bone mineral density （BMD） and vertebral fracture in Shanghai postmenopausal women. We also compared the ability of these two screening tools to predict osteoporosis and vertebral fracture. Methods 988 postmenopausal women were included： 494 with vertebral fractures and the other 494 without. BMD at spine and proximal femur were measured by dual-energy X- ray absorptiometry. OSTA and STLBMS indices were calculated. Results Both indices demonstrated that the fracture group had higher risk indices（ P 〈 0.001 ）. Both groups showed that higher risk indices with STLBMS index（ P 〈 0.001 ）. BMD at the L1_4 and proximal femur showed positive correlation with OSTA and STLBMS index （r = 0.336-0.562 and r = 0.383-0.57, all P 〈 0.001）. These two methods correlated more significantly（ r = 0.974, P 〈 0.001）. The OSTA values of ≤ - 1 and STLBMS values of ≤5 could diagnose osteoporosis with an area under curve （AUC） of 0.73 and 0.74. They could predict postmenopausal vertebral fracture with an AUG of 0.55 and 0.57. Conclusions We concluded that OSTA and STLBMS positively correlated with BMD and might be helpful to identify postmenopausal women increased risk of vertebral fracture. Our data showed no difference between the ability of these two screening tools to predict osteoporosis and vertebral fracture. Both of them were ideal tools for screening osteoporosis.
出处
《中国骨质疏松杂志》
CAS
CSCD
2009年第6期395-399,共5页
Chinese Journal of Osteoporosis
基金
国家自然科学基金资助项目(30570891,30771019和30800387)
上海市科委优秀学科带头人计划资助项目(08XD1403000)
关键词
骨密度
椎体骨折
骨质疏松
筛选工具
Bone mineral density
Vertebral fracture
Osteoporosis
Screening tool
