摘要
中药的临床应用建立在辨证的基础上,因此其药效评价也应该建立在中医证候分类的基础之上。通过药效学实验阐明中药治疗疾病的药效作用特点及其机制,揭示中药作用机制的科学内涵,是中药现代化和国际化的必然要求,也是探索药物作用靶点,指导临床合理用药的关键所在。如何利用成熟疾病动物模型,并明确其证候特征,是中药药效评价载体研究的关键问题。随着生物医学的发展,通过研究疾病动物模型的生物学指标有可能分析得出该疾病动物模型的证候特性。利用以方测证方法,建立针对该疾病常见证候类型且临床验证有效的中药干预疾病动物模型,并将治疗有效的动物作为体现相应证候特征的动物模型,通过探寻其现代生物学基础,确立相应的中医证候特征相关指标,从而明确疾病动物模型的证候特征,是建立适合辨证论治中药药效评价动物模型的重要途径。建立基于中医证候分类的中药药效评价研究方法,将有助于从中医理论出发提高我国中药研发水平。
The clinical application of Chinese herbal medicine should be based on syndrome differentiation in traditional Chinese medicine （TCM）, and the pharmacological evaluation of herbal medicine in new drug discovery should be also based on the TCM syndrome differentiation. To clarify the Chinese herbal characteristics and mechanisms of action through pharmacological experiments is not only the inevitable requirement for Chinese herb modernization and internationalization, but also the key way to direct the clinical rational administration. Thus how to characterize the syndrome type in commonly used animal disease models becomes the key issue in pharmacological evaluation. Following the development of biomedicine, one important way to clarify the syndrome characteristics of animal disease model in the pharmacological evaluation is to compare the differences between the responsive and non-responsive animals, and to find out the responsiveness-related biocharacteristics. An important approach to set up the Chinese herbal pharmacological evaluation which is suitable for Chinese medicine differentiation is to utilize the method of surveying syndrome type with Chinese herb formula and select the responsive animal model to reflect certain syndrome type, and furthermore to clear up the syndrome characteristics of the animal model by investigating its modern biological basis and establishing the correct indications of special TCM syndrome type. This pharmacological evaluation way based on finding out the responsiveness-related biocharacteristics of herbal medicine could become more effective in evaluating drug effects, further improving the new drug discovery, and developing Chinese herbal medicine.
出处
《中西医结合学报》
CAS
2009年第6期501-504,共4页
Journal of Chinese Integrative Medicine
基金
国家"十一五"支撑计划项目(No.2006BAI08B01-01
No.2006BAI04A10)
关键词
中药
治疗效果
证候
模型
动物
Chinese herbal drugs
treatment effectiveness
syndrome
models, anima
