摘要
目的：探讨Claudins蛋白与食管癌的发生发展之间的关系。方法：通过对最近一些研究报道及文献资料的整理，总结Claudins蛋白在食管癌中的表达情况。结果：不同类型的Claudins蛋白基因在不同组织类型食管癌中的表达不同，并且有着不同的机理。结论：就目前的研究报道，Claudins蛋白在Barrett’s食管和食管腺癌中的表达升高，在食管鳞癌中表达下降或表达不变，Claudins蛋白对食管癌的诊断、治疗有着很大的前景：
Objective：To explore the relationship between Claudins protein and incidence of esophageal cancer. Methods ： To review and analyze some literatures and reports concerning the expression of Claudins protein in esophageal cancer tissues. Results ： Different types of Claudins protein were expressed in different esophageal cancers, depending on different mechanisms. Conclusions：Up to now, most researchers consider that, the expression of Claudins protein in Barrett＇s esophagus and adenocarcinoma of esophagus was increased, but was decreased or remained constant in squamous cell carcinoma of esophagus. Claudins protein has a great potential value in the diagnosis and treatment of esophageal carcinoma.
出处
《解剖与临床》
2009年第3期215-217,共3页
Anatomy and Clinics
