摘要
目的探讨血清脂联素、抵抗素与c反应蛋白（CRP）在动脉粥样硬化发生发展过程中的作用及病理生理意义。方法选取老年不稳定心绞痛（UAP组）和急性心肌梗死（AMI组）患者各18例和20例正常人（对照组），检测三组血清脂联素、抵抗素、CRP水平进行比较。结果冠心病患者血清抵抗素、CRP水平高于对照组（P〈0．05），AMI组高于UAP组（P〈0．05）；脂联素水平在冠心病组低于对照组（P〈0．05），AMI组低于UAP组；血清脂联素水平与抵抗素、CRP水平呈负相关，抵抗素水平与CRP水平正相关。结论脂联素和抵抗素是冠状动脉疾病的独立危险因素，可作为判断冠状动脉病变程度的指标。CRP是敏感的炎症指标，具有促炎效应。三者之间的关系共同促进了动脉粥样硬化的发展。
Objective To evaluate the possible roles of the serum level of adiponetin, resistin and CRP in old patients with CHD and their functions in the devolopment of the AS. Methods 20 normal control subjects（ normal group） and 18 old patients with UAP （ UAP group） and 18 old patients with AMI（ AMI group）. Serum level of diponetin ,resistin and CRP were measured in three groups and compared the results. Results The serum level of CRP,resistin increased but the serum level of adponetin decreased in CHD patients compared with normal group（P 〈 0. 05 ） ;The serum level of adiponetin and resistin, CRP were negatively correlated, but th serum level of resistin and CRP were positively correlated. Conclusion Adiponectin and resistin may be important risk factors in coronary artery disease and can be used to evaluate the degree of CAD~ CRP is a sensitive inflammtory marke, it has a remarkble effect to the inflammtory and participates in the devolopment of the AS. The correlation of them with CRP may promote the development of atherosclerosis.
出处
《中外医学研究》
2009年第4期4-7,共4页
CHINESE AND FOREIGN MEDICAL RESEARCH
