摘要
人体的肝脏、肾脏和肠道上广泛分布有各种转运蛋白,其中有机阳离子转运体(OCTs)负责转运一些内、外源性的有机阳离子的转运。在此我们主要讨论的是OCTs家族的成员OCT1和OCT2的基因多态性以及其功能意义。同时我们也就OCT对于药物代谢动力学以及药效学的影响进行阐述,以及OCTs在药物相互作用上的意义。
Various kinds of transporters exist in human organs, such as liver, kidney and intestine. The transport of cationic substrates which include endogenous metabolites, exotic substance, and drugs was mainly executed by different organic cation transporters （OCTs）. In this article the genetic polymorphisms and their influences on OCTs funtions were mainly reviewed. Meanwhile, the recent findings of OCTs polymorphism influences on pharrnacodynamics and pharmacokinetics value of several clinical widely used drugs were also included in this review.
出处
《中国临床药理学与治疗学》
CAS
CSCD
2009年第4期460-465,共6页
Chinese Journal of Clinical Pharmacology and Therapeutics
