摘要
猪传染性胸膜肺炎是由胸膜肺炎放线杆菌(App)引起的一种呼吸道传染性疾病。根据荚膜多糖和脂多糖抗原表位不同,将胸膜肺炎放线杆菌分为15个血清型,不同血清型的菌株毒力大小不同,致病性也有强弱之别。研究发现与App致病性有关的毒力因子包括荚膜多糖、脂多糖、外膜蛋白、转铁结合蛋白、溶血外毒素等,其中溶血外毒素是App引起猪致病最主要的毒力因子,也是主要的保护性抗原。论文从猪传染性胸膜肺炎溶血外毒素的分子结构、致病机制、免疫原性几个方面对其进行综述,为获得以Apx为抗原制备减毒活疫苗提供参考资料。
Actinobacillus pleuropneumoniae （App） is the aetiological agent of porcine pleuropneumonia, a highly contagious and often fatal disease. Fifteeen serotypes in Actinobacillus pleuropneumoniae are classified based on the cluster positions of the capsular polysaecharide and lipopolysaceharide antigens. Different App serotypes exhibit different virulence and pathogenicity. Virulence of A. pleuropneumoniae is caused by several factors, such as capsular polysaccharide, lipopolysaccharide, outer membrane proteins, iron uptake proteins, and Apx toxins. The extracellular hemolytic toxins of Actinobacillus pleuropneumoniae are thought to be important factors in this microorganism＇s virulence and immunity. This article reviewed the molecular structure,the pathopoiesis mechanism and the immunogenicity of Apx toxins.
出处
《动物医学进展》
CSCD
北大核心
2009年第6期82-85,共4页
Progress In Veterinary Medicine
关键词
胸膜肺炎放线杆菌
外毒素
免疫
Actinobacillus pleuropneumoniae
Apx toxin
immunity
