摘要
ＥｆｅｃｔｏｆｐｒｏｃａｉｎａｍｉｄｅｏｎｕｌｔｒａｓｔｒｕｃｔｕｒｅｏｆｂｌｏｏｄｐｌａｔｅｌｅｔｉｎｒａｂｂｉｔｓＬＩＵＬｉａｎＰｕ，ＳＨＡＮＣｈｕｎＷｅｎ１，２，ＬＩＵＸｉＨｏｎｇ，ＸＩＡＯＨｕａｎＣａｉ，ＹＡＮＧＳｈｕＱｉｎ１（Ｄｅ...
AIM: To study the effect of procainamide (PA) on the ultrastructure of blood platelets. METHODS: Arachidonic acid was added to PA treated platelet rich plasma to induce platelet aggregation. The 50 nm sections were examined with a transmission electron microscope. RESULTS: PA 8 5-136 μmol·L -1 markedly inhibited changes of pseudopods, α granules, dense granules, glycogens, open canalicular system,and dense tubular system. CONCLUSION: PA markedly inhibited the changes of ultrastructure of blood platelet and releasing response.
出处
《中国药理学报》
CSCD
1998年第4期376-379,共4页
Acta Pharmacologica Sinica
关键词
普鲁卡因胺
血小板聚集
超微结构
procainamide
arachidonic acids
platelet aggregation
electron microscopy
