摘要
肌肉运动可以激活一些生长因子,这些生长因子是肌肉蛋白质合成的有力刺激物。mTOR信号转导通路通过增加特异性mRNA的翻译从而在不同水平上控制蛋白质合成,mTOR是被其上游信号PI3K和Akt所激活的,最后在力学负荷过载的情况下激活其效应子p70s6k。运动经由PI3K/Akt/mTOR/p70s6k信号转导通路能有效刺激肌肉合成代谢信号分子的激活。虽然对磷脂酸、整联蛋白的研究已经取得了一定的进展,但是还有一些问题需要进一步研究,特别是其与mTOR信号转导通路的关系。由于不同的运动模式对于mTOR/p70s6k信号通路的影响是不一样的,因此更详细地了解不同运动模型的类型、强度和时间,有利于更好地了解mTOR/p70s6k信号转导通路。
The Muscle contraction can activate some growth factor, which is the powerful stimulant for muscle protein synthesis. The mTOR signaling pathway controls the synthesis of proteins through its regulation of increasing specific mRNA the translation. mTOR, which activated by its upstream signal PI3K and Akt, stimulates sub-p70s6k under mechanics overloads. Exercise induced PI3K/Akt/mTOR/p70s6k signal transduction circuit can effective stimulus the activation of signal factors of muscle protein synthesis metabolism. Studies regarding phosphatidic acid, Jntegrin had made certain progress, but there still has some questions need to be solved, specially the relationship between phosphatidic acid, integrin and roTOR signal transduction circuit. Different exercise model has different influence on mTOR/p70s6k signaling pathway. Therefore, in order to further understand the mTOR/p70s6k signaling pathway, it is necessary to realizing the effect of different mode, intensity and duration of exercise on it.
出处
《中国组织工程研究与临床康复》
CAS
CSCD
北大核心
2009年第24期4738-4741,共4页
Journal of Clinical Rehabilitative Tissue Engineering Research
