摘要
目的．探讨帕金森病患者直立性低血压与性别、年龄、病程、左旋多巴剂量、治疗时间及Hoehn—Yahr分级之间的关系。方法166例帕金森病患者，测量直立位1和5min时血压和心率，记录性别、年龄、病程、左旋多巴剂量及治疗时间。采用帕金森病统一评价量表第3部分（UPDRSⅢ）和HoehnYahr分级评价其运动功能和疾病严重程度。结果166例患者，76例（45．78％）直立位血压无明显变化；30例（18．07％）直立位1min时血压下降，至直立位5min时血压恢复至正常值范围；60例（36.14％）至直立位5min时血压未恢复至正常值范围，其中28例（16．87％）诊断为直立性低血压。各组患者年龄（F=3．448，JP=0．018）、病程（H=19．834，P=0．000）、左旋多巴剂量（H=16．890，P=0．000）、治疗时间（H=19．543，P=0．000），UPDRSⅢ评分（F=33．542，P=0．000）及Hoehn-Yahr分级（H=48．215，P=0.000）比较，差异有统计学意义。以病程作为校正因素，年龄（r=0．212，P：0．015）、UPDRSⅢ评分（r=0．616，P=0．000）和Hoehn—Yahr分级（r=0．487，P=0．000）与直立性低血压呈正相关；以Hoehn-Yahr分级作为校正因素，病程与直立性低血呈正相关（r=0．174，P=0．025）。结论帕金森病患者直立性低血压主要与疾病严重程度相关，亦与年龄和病程相关，而与左旋多巴剂量和治疗时间无关。
Objective To study the relationship of orthostatic hypotension （OH） with sex. age, duration, dosage of levodopa, time of treatment and Hoehn-Yahr Scale in Parkinson disease （PD）. Methods The blood pressure （BP） and heart rate （HR） of 166 patients with PD were measured at 1 and 5 rain after standing up. According to the descendent degree of BP, the patients were divided into 4 groups. The sex. age, duration, dosage of levodopa and time of treatment were recorded. Unified Parkinson Disease Rating Scale Ⅲ （UPDRS Ⅲ） was used for motor function assessment, and Hoehn-Yahr Scale was applied to evaluate severity of disease. Results In 166 PD patients, orthostatic BP of 76 cases （45.78%） did not change significantly, while the BP of 90 cases （54.21%） decreased at 1 min after standing up and returned to normal range at 5 min in 30 cases （18.07%）, but 60 cases （36.14%） did not. Among them, 28 cases （16.87%） were diagnosed as OH. The age （F= 3.448, P= 0.018）, duration （H = 19.834, P = 0.000）, dosage of levodopa （H = 16.890. P= 0.000）, time of treatment （H = 19.543, P= 0.000）, UPDRS Ⅲ score （F= 33.542, P= 0.000） and Hoehn-Yahr Scale （H = 48.215, P= 0.000） were different significantly among 4 groups. After adjusted the duration factor, the descendent degree of OH and age （r=0.212, P=0.015）, UPDRSⅢ score （r=0.616, P=0.000） and Hoehn-Yahr Scale （r= 0.487, P= 0.000） were all correlated positively. When Hoehn-Yahr Scale was adjusted, the descendent degree of OH was correlated positively with duration （r = 0.174, P = 0.025）. Conclusion The occurrence of OH is predominantly related with the severity of PD. It is also related with age and duration. There is no correlation of the abnormal BP response with dosage of levodopa and time of treatment.
出处
《中国现代神经疾病杂志》
CAS
2009年第3期261-265,共5页
Chinese Journal of Contemporary Neurology and Neurosurgery
关键词
帕金森病
低血压
直立性
因素分析
统计学
Parkinson disease
Hypotension, orthostatic
Factor analysis, statistical
