摘要
目的探讨尿微量白蛋白与肌酐比值(Malb/Cr)在糖尿病肾病早期诊断中的价值。方法应用日立7060型全自动生化分析仪检测Ⅱ型糖尿病患者124例及健康者58例尿液中微量白蛋白与肌酐的含量。结果糖尿病患者尿液Malb/Cr对数值明显高于健康者(P<0.001)。糖尿病患者尿液Malb/Cr对数值与血糖无相关性(r=0.001),与24h尿蛋白定量有低度的等级正相关(r=0.403)。结论糖尿病患者尿液Malb/Cr升高可提示早期肾损伤,对糖尿病肾病的早期诊断具有重要价值。
Objective To study the significance of urinary Malb/Cr ratio in diagnosis of early diabetic nephropathy. Methods The levels of urinary microablumin and creatinine were determined by Hitachi -7180 fully automatic biochemical analyzer in 124 patients with type Ⅱ diabetes mellitus and 58 healthy controls. Results The logarithm of urinary Malb/Cr in diabetes group was significantly higher than that of healthy group（ P 〈0. 001 ）. The logarithm of urinary Malb/Cr was not correlated with blood level of glucose （ r =0. 001 ） in diabetic nephropathy, and it was related with amount of 24 hours urinary protein （ r = 0. 403 ）. Conclusion The increase in urinary Malb/Cr indicates the early renal damage in diabetes patients, and it has great significance in diagnosis of early diabetic nephropathy.
出处
《临床和实验医学杂志》
2009年第6期11-12,共2页
Journal of Clinical and Experimental Medicine
