摘要
目的:观察还原型谷胱甘肽联合多烯磷脂酰胆碱治疗非酒精性脂肪性肝病的疗效。方法:将60例非酒精性脂肪性肝病患者随机分为2组,治疗组30例,静脉滴注多烯磷脂酰胆碱10mL+还原型谷胱甘肽1200mg,每日1次;对照组30例,多烯磷脂酰胆碱10mL,每日1次。2组疗程均为1个月。治疗前、后分别检查肝功能、血脂及肝脏彩超以判断治疗效果。结果:治疗组在降低丙氨酸氨基转移酶、天门冬酸氨基转移酶、γ-谷氨酰转移酶方面有效率达90.0%,与对照组(63.3%)比较有显著性差异(P<0.05);在降低总胆固醇、甘油三酯方面2组无显著性差异(P>0.05)。结论:还原型谷胱甘肽联合多烯磷脂酰胆碱治疗非酒精性脂肪性肝病有良好疗效。
OBJECTIVE： To observe the clinical efficacy of reduced glutathione combined with Polyene Phosphatidyl- choline for non - alcoholic fatty liver disease. METHODS： 60 patients with non - alcoholic fatty liver disease were randomly divided into trial group and control group： 30 patients in trial group were infused iv gtt with Polyene Phosphatidylcholine （10 mL） and reduced glutathione （1 200 mg） once daily for 1 months, and 30 in control group with Polyene Phosphatidylcholine （10 mL） once daily for 1 months. Parameters of liver function and blood lipid and color ultrasonic examination of two groups before and after treatment were compared for evaluation of therapeutic effects. RESULTS： In respect of the reduction of alanine aminotransferase （ALT）, aspartate aminotransferase fAST） and 7-GT, there were significant differences between the trial group and the control group in the effective rate （90.0% in trial group versus 63.3 % in control group, P〈0.05）. However, there were no significant differences between the two groups in the reduction of total cholesterol （TG） and triglyc- eride （TC） （P 〉 0.05） . CONCLUSION： Used concomitantly, reduced glutathione and Polyene Phosphatidylcholine showed satisfactory efficacy for non - alcoholic fatty liver disease.
出处
《中国药房》
CAS
CSCD
北大核心
2009年第17期1328-1330,共3页
China Pharmacy
