摘要
目的:比较不同比重左旋布比卡因在高龄患者腰麻-硬膜外联合麻醉经尿道前列腺电切术(TURP)中的麻醉效果及安全性。方法:择期行TURP高龄患者60例随机分成3组,每组20例。组Ⅰ用轻比重左旋布比卡因,即0.75%左旋布比卡因1mL+0.9%氯化钠注射液0.5mL;组Ⅱ用等比重左旋布比卡因,即0.75%左旋布比卡因1mL+脑脊液0.5mL;组Ⅲ用重比重左旋布比卡因,即0.75%左旋布比卡因1mL+10%葡萄糖注射液0.5mL。结果:3组均能提供较为完善的麻醉。组Ⅲ的低血压和恶心、呕吐及寒战发生率明显低于组Ⅰ、组Ⅱ(P<0.05),组Ⅲ的最高阻滞平面明显低于组Ⅰ、组Ⅱ(P<0.05)。结论:重比重左旋布比卡因用于高龄患者腰麻-硬膜外联合麻醉,对血流动力学的影响最小,不良反应发生率低,安全、有效。
OBJECTIVE： To compare the efficacy and safety of different density of Levobupivacaine for combined spinal and epidural anesthesia （CSEA） in elder patients. METHODS： Sixty elder patients undergoing transurethral prostatectomy （TURP） were randomly assigned to 1 of the 3 groups： Group I （n = 20, hypobaric group） received 0.75% Levobupivacaine 1 mL ＋ 0.5 mL 0.9% Sodium Chloride Injection, Group Ⅱ （n = 20, isobaric group） received 0.75% Levobupivacaine 1 mL ＋ 0.5 mL cerebrospinal fluid, and Group Ⅲ （n = 20, hyperbaric group） received 1 mL 0.75% Levobupivacaine ＋ 0.5 mL 10% Glu- cose. RESULTS： All the 3 groups achieved satisfactory anesthetic efficacy. The incidences of hypotension, nausea, vomiting and shivering were significantly lower in Group Ⅲ than in other two groups （Group I and Group Ⅱ ） （P〈0.05）, and the highest block level was significantly lower in Group Ⅲ than in other two groups（P 〈 0.05） . CONCLUSION： The hyperbaric Levobupivacaine was proved to be safe and effective for CSEA in eider patients, and its effect on hemodynamics and the inci- dences of its side effects were the lowest.
出处
《中国药房》
CAS
CSCD
北大核心
2009年第17期1326-1328,共3页
China Pharmacy
