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经内镜大肠黏膜下层剥离术(ESD)—现状和展望 被引量:18

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摘要 不论病灶大小,经内镜黏膜下层剥离术(ESD)都能一次性整体切除。在日本,ESD已被确认为上消化道(GI)恶性肿瘤内镜切除的标准方法。尽管ESD治疗大肠病变的研究已通过临床验证,但ESD尚未被确认是大肠病变的标准治疗方法,因为大肠癌具有独特的病理学和特异器官的特征,从根本上就不同于食管和胃,大肠内镜比上消化道(GI)内镜的镜下操作和控制更为困难。根据内镜黏膜切除术(EMR)的疗效和大肠癌的临床病理学特征,建议大肠内镜黏膜下层剥离术(ESD)的适应症如下:①用EMR圈套切除术难以整体切除的病变,例如非颗粒状侧向发育型肿瘤((laterally spreading tumor,LST-NG),尤其是假凹陷型(pseudo depressed type),大肠腺管开口形态(pit pattern)表现为ⅤI型病变,怀疑恶性的隆起型病变;②活检或炎症导致的纤维化病变;③慢性炎症导致的散发、局灶性病变,例如溃疡性结肠炎;④EMR术后局部残留癌。目前大肠ESD正处于发展阶段,在不久的将标准方案即将出台。我们希望,依靠放大、光学染色内镜等技术作出精确的术前诊断,适当选择EMR,ESD和手术切除,使大肠肿瘤得到有效的治疗。
作者 韩英
机构地区 北京军区总医院
出处 《现代消化及介入诊疗》 2009年第2期63-66,共4页 Modern Interventional Diagnosis and Treatment in Gastroenterology
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参考文献13

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