摘要
肠易激综合征（IBS）是与肠道动力和内脏感觉异常有关的功能性胃肠病。心理、社会、环境、遗传等因素在发病过程中起极为重要的作用。IBS多发生在伴有不同程度心理调节障碍、具有遗传特征的易患群体．有明显的家庭聚集现象。当前公认的罗马Ⅲ诊断标准是以临床症状学为依据，部分符合诊断标准的IBS患者．其肠黏膜可能存在免疫细胞浸润、免疫激活和轻微黏膜炎症，这种炎症在IBS中的潜在作用已引起人们的关注．目前尚无一种药物对IBS的治疗完全有效，IBS的治疗应遵循个体化治疗的原则，采取综合性治疗措施。未来需对IBS的病理学、免疫学和肠内微生态学有更全面的认识．以进一步思考IBS的诊断方式和标准。
Irritable bowel syndrome （IBS） is a functional gastrointestinal disorder related with intestinal dysmotility and visceral paresthesia. Psychological, social, environmental and hereditary factors play crucial roles in the pathogenesis of IBS. Most patients have different degree of psychological problems and hereditary features, and have obvious family- clustered phenomena. The well-accepted Rome Ⅲ diagnostic criteria are based on clinical symptoms. Immune cell infiltrations, activation of immune system and slight inflammation in intestinal mucosa have been seen in some of the IBS patients diagnosed by the symptomatic criteria. The potential role of inflammation in IBS has evoked more and more attention. By now, there is still no drug having complete response, and the main principles to be followed in the treatment of IBS are individualization and use of comprehensive regimen. More and overall information about the pathology, immunology and intestinal microecology is needed to revise the diagnostic paradigm and criteria.
出处
《胃肠病学》
2009年第5期257-260,共4页
Chinese Journal of Gastroenterology
关键词
肠易激综合征
遗传
免疫
肠黏膜
炎症
Irritable Bowel Syndrome
Heredity
Immunity
Intestinal Mucosa
Inflammation
