摘要
目的探讨应用氯己定液行口腔护理对机械通气相关性肺炎(VAP)的影响。方法对2006年1月-2007年12月ICU及CCU收治的须行机械通气的99例患者,分为两组,分别应用0.5%氯己定液与生理盐水进行口腔护理,观察两组患者的VAP发生率、口咽部与气管内细菌定植情况等。结果试验组有14例(26.41%)发生VAP,对照组有23例(50.00%)发生VAP,两组患者在年龄、性别、基础疾病、插管前急性生理与慢性健康评分(APACHEⅡ)及临床肺部感染评分(CPIS)等方面差异无统计学意义(P>0.05),试验组中早发型VAP有4例(28.57%),对照组中早发型VAP有12例(52.17%),两组之间差异有统计学意义(P<0.05)。结论使用氯己定溶液行口腔护理可以减少和延缓VAP的发生,是一种安全有效的口腔护理方法。
OBJECTIVE To evaluate the oral decontamination effect of chlorhexidine on ventilator-associated pneumonia. METHODS One hundred and eight patients needing mechanical ventilation were randomly divided into two groups. This was a double-blind and placebo-controlled trial. Placebo group decontaminated oral cavity with saline and test group with 0. 5% chlorhexidine. Finally we compared difference of the incidence of VAP, oropharyngeal colonization and endotraeheal colonization between two groups. RESULTS There were no statistic differences between two groups in the age, gender, constituent ratio of underlying disease, APACHE Ⅱ and clinical pulmonary infection scores（CPIS）. The incidence of VAP, early onset VAP, oropharyngeal colonization and endotracheal colonization in test group was statistically lower than those in placebo group. CONCLUSIONS Oropharyngeal deeontamination with ehlorhexidine reducg and delays the development of VAP in patients receiving mechanical ventilation. It is a safe and effective antiseptic solution in oral care.
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2009年第11期1383-1384,共2页
Chinese Journal of Nosocomiology
