C225的生物学特性及在头颈部肿瘤中的应用
摘要
C225是一种EGFR为靶点的人鼠嵌合型IgG1单克隆抗体,与放疗和/或化疗联合应用时具有协同作用,可以增加患者的放化疗疗效。目前,C225已用于结直肠癌和头颈部肿瘤的治疗,并取得了非常好的疗效。
出处
《西部医学》
2009年第6期1024-1026,共3页
Medical Journal of West China
参考文献10
-
1Goldberg RM.Cetuxi mab[].Nature Reviews Drug Discovery.2005 被引量:1
-
2Ki mura H,Sakai K,Arao T,et al.Antibody-dependent cellularcytotoxicity of cetuxi mab against tumor cells with wild-type ormutant epidermal growth factor receptor[].Cancer Science.2007 被引量:1
-
3Peng D,Fan Z,Lu Y,et al.Anti- epidermal growth factor receptor monoclonal antibody 225 up-regulates p27kip1 and induces G1 arrest in prostatic cancer cell line DU 1451[].Cancer Research.1996 被引量:1
-
4Perrotte P,Matsumoto T,Inoue K,et al.Anti-epidermal growth factor receptor antibody C225 inhibits angiogenesis in human transitional cell carcinoma growing orthotopically in nude mice[].Clinical Cancer Research.1999 被引量:1
-
5Robert F,Ezekiel M P,Spencer S A,et al.Phase I study of anti-epidermal growth factor receptor antibody cetuximab in combination with radiation therapy in patients with advanced head and neck cancer[].Journal of Clinical Oncology.2001 被引量:1
-
6Bonner JA,Harari PM,Giralt J,et al.Radiotherapy plus cetuximab for squamous-cell carcinoma of the head and neck[].The New England Journal of Medicine.2006 被引量:1
-
7Humbler Y.Cetuximab:an IgG(1)monoclonal antibody for the treat- ment of epidermal growth factor receptor-expressing tumours[].Expert Opinion on Pharmacotherapy.2004 被引量:1
-
8Wu X,Rubin M,Fan Z,et al.Involvement of p27kip1 in G1 arrest mediated by an anti-epidermal growth factor receptor monoclonal antibody[].Oncegene.1996 被引量:1
-
9Liu B,Fang M,Lu Y,et al.Fibroblast growth factor and insulin-like growth factor differentially modulate the apoptosis and G1 arrest induced by anti-epidermal growth factor receptor monoclonal antibody[].Oncegene.2001 被引量:1
-
10SM Huang,J Li,PM Harari.Molecular inhibition of angiogenesis and metastatic potential in human squamous cell carcinomas after epidermal growth factor receptor blockade[].Molecular Cancer Therapeutics.2002 被引量:1
-
1王道军,刘阿海,靳桂红.西妥昔单抗联合化疗在消化系统肿瘤中的应用[J].肿瘤基础与临床,2014,27(5):423-424.
-
2钱芳,孙俊华.氟化钠致人鼠染色体畸变和精子研究[J].暨南大学学报(自然科学与医学版),1990,11(2):16-22.
-
3黄晓,吉柳.西妥昔单抗致过敏反应1例[J].中国医院用药评价与分析,2017,17(2):287-288. 被引量:2
-
4顾佳佳,尹丽,何侠.西妥昔单抗在鼻咽癌中的研究进展及临床应用[J].肿瘤学杂志,2016,22(3):230-235. 被引量:1
-
5梁喆,卢连军,李海凤,高磊,米力.人(人-鼠)及人-鼠杂交瘤中A型逆转录病毒的观察[J].上海免疫学杂志,1991,11(5):271-272.
-
6樊瑞娟.利妥昔单抗联合CHOP方案治疗B细胞型非霍奇金淋巴瘤患者的护理[J].中华现代护理杂志,2009,15(2):155-155. 被引量:2
-
7刘翠珍,刘汉锋.B细胞恶性肿瘤单克隆抗体治疗新进展[J].内科,2011,6(1):52-55. 被引量:2
-
8孙雪菊,李学.西妥昔单抗联合放化疗治疗中晚期恶性肿瘤的研究进展[J].中国现代医生,2009,47(35):21-22. 被引量:3
-
9刘睿,石莹,张宏,戴弘,陈列松,张晓慧,孙谕,朱榕嘉,陈萍,傅晋翔.一种新人鼠多发性骨髓瘤模型的建立及特性研究[J].中华血液学杂志,2009,30(9):631-634.
-
10刘辉,陈红莲,袁磊.Notch3诱导人小细胞肺癌H446细胞G_0/G_1期阻滞及其机制[J].解剖学报,2016,47(6):791-795. 被引量:2