摘要
目的探讨单味栀子水煎剂对离体兔Oddi括约肌收缩活动的影响。方法将Oddi括约肌环放置于灌流肌槽中,累积加入不同浓度栀子水煎液,记录肌肉收缩活动的变化。结果栀子水煎剂可浓度依赖性地提高Oddi括约肌张力和收缩波频率(r=0.95,P<0.01;r=0.97,P<0.001),对Oddi括约肌自发性节律收缩具有明显的兴奋作用,而且不受六烃季胺及消炎痛的影响,但部分被阿托品所拮抗。结论栀子对Oddi括约肌自发性节律收缩的兴奋作用可能部分经由M受体介导。
Objective To investigate the effects of Gardenia jasminoides on he contractile activity of ex vivo sphincter of Oddi of rabbits. Methods Different concentrations of water decocting Gardenia jasminoides were administered to ex vivo sphincter of Oddi of rabbits in perfusion muscular socket, and the activities of muscle contraction were recorded. Results Water decoction of Gardenia jasminoides significantly increased muscular tension and the frequency of contraction wave of the sphincter of Oddi of rabbits in a concentration-dependent manner （r=0.95, P 〈0.01; r=0.97, P 〈0.001）, and had obvious excitatory effects on its spontaneous rhythmic contraction, which could not be blocked by hexamethonium and indomethacin but could partly be blocked by atropine. Conclusion The excitatory effects of Gardenia jasminoides decoction on the spontaneous rhythmic contraction of the sphincter of Oddi of rabbits may be partly mediated by cholinergic M receptor.
出处
《兰州大学学报（医学版）》
CAS
2009年第2期5-8,共4页
Journal of Lanzhou University（Medical Sciences）
基金
甘肃省科学事业费(QS992-C33-022-15)
关键词
栀子
ODDI括约肌
自发性节律收缩
张力
Gardenia jasminoides
the sphincter of Oddi
spontaneous rhythmic contraction
tension
