摘要
报道了用碳糊电极测定甲硝唑的方法。在ｐＨ３．２的ＬｉＣｌ－ＨＣｌ电解溶液中，用二次导数阴极溶出伏安法测定甲硝唑。在碳糊电极上开路富集甲硝唑６０ｓ，然后记录其在－０．５８Ｖ的二次导数阴极溶出峰。溶出峰电流ｉｐ与甲硝唑浓度在３．０×１０－７～３．０×１０－６ｍｏｌ／Ｌ和３．０×１０－６～１．０×１０－４ｍｏｌ／Ｌ范围内呈良好的线性关系，相关系数分别为０．９９８６和０．９９９７，检出限为１．７×１０－７ｍｏｌ／Ｌ，相对标准偏差为６．０％（ｎ＝１０）。本方法直接用于甲硝唑片剂的测定，并用多种方法对甲硝唑在碳糊电极表面的反应机理进行了探讨。
The measurement of metronidazole (MTZ) (1-(2-hydroxyethyl)-2-methyl 5-nitroimidazole) with carbon paste electrode is descirbed.The electrochemical interaction mechanism on this electrode for MTZ was studied by electrochemical method.MTZ was accumulated in lithium chloridehydrochloric acid (pH 3.2) medium at the electrode in an open circuit,and then it was determined by secondderivative cathodic stripping voltammetry.The reduction peak of MTZ was observer at -0.58V.The relationship between the peak current and MTZ concentration was linear in the ragne of 3.0×10-7to 3.0×10-6mol/L and 3.0×10-6to 1.0×10-4mol/L .The correlation coefficients were 0.9986 and 0.9997,respectively,A detection limit of 1.7×10-7mol/L for MTZ was obtained.The relative standard deviation was 6.0% (n=10).The method has been applied to the determination of MTZ in MTZ tablet with satisfactory results.
出处
《分析试验室》
CAS
CSCD
1998年第3期40-43,共4页
Chinese Journal of Analysis Laboratory
基金
河南省自然科学基金
关键词
甲硝基羟乙唑
MTZ
甲硝唑
测定
碳糊电极
分析
Metronidazole deterction
carbon paste electrode
cathodic stripping voltammetry
