摘要
用分子连接性指数及比较分子力场分析分别研究了苯甲酰胺类化合物的结构与抗炎活性的关系，结果表明：三维空间上立体效应是描述该类化合物的抗炎活性和进行结构与性能关系研究的最重要的结构参数．
Molecular connectivity index and comparative molecular field analysis (CoMFA)have been applied to the studies of the correlation of the derivatives of benzamide and their antiallergic activities. The results achieved by using CoMFA based on 3D factors are much better than that obtained by using multiple regression analysis based on majorly 2D structural information. The CoMFA results show that the dominant factor which affects activity is steric, whereas electrostatic effect only plays an unimportant role.
出处
《高等学校化学学报》
SCIE
EI
CAS
CSCD
北大核心
1998年第5期294-298,共5页
Chemical Journal of Chinese Universities
基金
国家自然科学基金
