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新辅助化疗对大肠癌细胞凋亡的研究

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摘要 目的根据奥沙利铂+5-FU+CF新辅助化疗方案对大肠癌细胞凋亡的变化,判断大肠癌患者对该方案的敏感程度。方法大肠癌患者40例,分为低分化(含未分化)、中分化、高分化3组,根据同一患者化疗前、后的肿瘤细胞凋亡率(AI)变化,评估三组不同分化程度大肠癌患者对化疗方案的敏感性。结论化疗后的AI(29.4%)明显高于化疗前(13.5%),提示新辅助化疗对肿瘤细胞有显著的治疗作用,同时证实了奥沙利铂+5-FU+CF这一化疗方案对低、中、高分化大肠癌的疗效是确切的,并且分化程度与对化疗的敏感性成反比。
出处 《江西医药》 CAS 2009年第5期473-475,共3页 Jiangxi Medical Journal
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  • 1Kerr J F, Wyllie A H,Currie A R . Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics [J].Br J Cancer,1972,26(4): 239-257. 被引量:1
  • 2[1]Kerr JFR, Wyllie AH, Currie AR. Apoptosis: a basis biological phenomenon with wide-ranging implications in tissue kinetics[J].Br J Cancer, 1972, 26(3): 239 - 257. 被引量:1
  • 3[2]Vermes I, Haanen C, Steffens-Nakkn H, et al. A novel assay for apoptosis: flow cytomeric detection of phosphatidylserine expression on early apoptosis[J]. J lmmunol Met, 1995, 184(1):39-51. 被引量:1
  • 4[3]Arends MJ, Morris RG, Wyllie AH. Apoptosis: the role of the endonuclease[J]. Am J Pathol, 1990, 136(5):593-608. 被引量:1
  • 5[4]Ravnat C, Arehipoff G, Beretz A, et al. Use of annexin V to demonstrate the role of phosphatidyl serine exposure in the maintenance of haemoststic balance by endothelial cells[J]. Biochem J,1992, 282(ptl): 7-13. 被引量:1
  • 6[5]Sarraf CE, Bowen ID. Proportions of mitotic apoptosis cells in a range of untested experimental tumors [J]. Cell Tissue Kinet,1988, 21(1):45-49. 被引量:1
  • 7[6]Kasagi N, Gomyo Y, Shirai H, et al. Apoptosis cell death in haman gastric carcinoma: analysis by terminal deoxynucleotidyl transferase mediated dUTP-biotin nick end labelling[J]. Jpn J Cancer Res, 1994, 85(9):935-945. 被引量:1
  • 8[7]Jones NL, Shannon PT, Cutz E, et al. Increase in proliferation and apoptosis of astric epithelial cells early in the nature history of Helicobacter pylori infection[J]. Am J Pathol, 1997, 151 (6):1695 - 1703. 被引量:1
  • 9Fujii M,Kochi M,Mochizuki F.Significance of neoadjuvant chemotherapy for gastric cancer [J].Gan To Kagaku Ryoho,2000,27(11):2028-2032. 被引量:1
  • 10Shchepotin IB,Chorny V,Hanfelt J,et al.Palliative superselective intraarterial chemotherapy for advanced nonresectable gastric cancer [J].J Gastrointest Surg,1999,3(4):426-431. 被引量:1

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