摘要
目的探讨肿瘤坏死因子-α(TNF-α)在糖尿病肾病中的作用及他汀类药物对其的干预效果。方法采用链脲佐菌素(STZ)一次性腹腔注射建立糖尿病大鼠模型,给予氟伐他汀进行干预治疗8周,并设立相应对照组。观察药物对大鼠血糖、血脂、尿蛋白、肾功能以及血清和肾脏中TNF-α表达的影响。结果氟伐他汀对各组大鼠血糖(P>0.10)、血脂(P>0.10)无明显影响,但能减少糖尿病大鼠的尿蛋白排泄量(P<0.01)、降低血清TNF-α(P<0.05)和肾脏TNF-α的表达(P<0.01),减轻肾小球肥大和系膜增生。结论氟伐他汀可能通过对TNF-α的抑制减少糖尿病大鼠的尿蛋白排泄,减轻肾脏病变,延缓糖尿病肾病的发展,且此作用不依赖于他汀类药物的调脂作用。
Objective To investigate the effect of TNF-α on diabetic nephropathy and the interfering effect of fluvastatin on TNF-α.Methods Injecting STZ into abdomen of rats to establish diabetic rats model. After oral administration of fluvastatin for 8 weeks,the results were analyzed in blood sugar, blood fat,urine protein,renal function and the expression of TNF-α in serum and renal. Results Fluvastatin have very little effect on blood sugar（P〉0.10）and blood fat（P〉0.10）,but can reduce the excretion of urine protein （P〈0.01）, and the expression of TNF-α in serum （P〈0.05）and renal （P〈0.01）, mitigate the glomerular hypertrophy and mesangial proliferative.Conclusion Fluvastatin can inhibit the expression of TNF-α, so as to reduce the excretion of urine protein,mitigate the pathological changes of renal, retard the development of diabetic nephropathy, and this effect is not depend on the lipid-lowering effect of statins.
出处
《江西医药》
CAS
2009年第5期438-441,共4页
Jiangxi Medical Journal
