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吉米沙星对单核细胞产生TNF-α及IκB磷酸化的抑制效应研究

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摘要 目的探讨吉米沙星对单核细胞产生TNF-α及IκB磷酸化的影响。方法获取单核细胞,吉米沙星孵育后加入LPS刺激,ELISA检测TNF-α的产生,Western blotting检测IκB的磷酸化情况。结果吉米沙星能明显抑制LPS诱导的TNF-α产生,并能抑制IκB的磷酸化。结论吉米沙星可能通过抑制IκB的磷酸化而对发挥免疫系统的调控作用。
作者 欧阳占英
出处 《中国现代医生》 2009年第16期64-65,共2页 China Modern Doctor
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