摘要
目的观察库拉索芦荟冻干粉对家兔皮肤创面愈合的作用。方法建立家兔背部皮肤创伤模型,采用自身平行对照的方法,将16只家兔背部的64个创面分成库拉索芦荟治疗组、重组人表皮生长因子(rhEGF)对照组、云南白药对照组和生理盐水对照组,观察伤后不同时间创面的形态和组织学改变、创面的愈合时间和愈合率。结果经库拉索芦荟治疗后的家兔创面上皮化率、创面新生上皮面积较生理盐水组及云南白药组明显升高(P<0.05)。结论给予家兔创面库拉索芦荟治疗后可明显缩短愈合时间、提高创面上皮化率、加快肉芽组织的增生、明显促进皮肤创面的修复,其作用优于云南白药,与rhEGF促进皮肤创面愈合的作用相当。
OBJECTIVE To observe the effects of aloe on skin wound healing. METHODS The rabbit dersal trauma model was used. A total of 64 dorsal wounds in 16 rabbits were created and divided into the aloe treatment group, the rhEGF control group, Yunnan white powder control group and the physiologic saline control group. The appearance of wound healing and the changes of histology were observed. A mean healing time was calculated. RESULTS The epithelization rate of wound surface and the regeneration epithelium area of aloe treated group were obviously greater than that of the Yunnan white powder control group and the physiologic saline control group（P 〈 0.05）. CONCLUSION Aloe on the wound surface has great effects of shortening healing time, elevating the epithelization rate of wound surface, accelerating hyperplasia of granulation tissue and obviously promoting wound healing. The effect exceed Yunnan white powder and correspond to rhEGF.
出处
《华西药学杂志》
CAS
CSCD
北大核心
2009年第3期272-274,共3页
West China Journal of Pharmaceutical Sciences
