期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

Aurora蛋白激酶及其抑制剂的研究进展 被引量：3

New Advances in Aurora Kinase and Its Anti-tumor Inhibitors
原文传递
导出
摘要 Aurora激酶是一类在细胞周期调控中具有重要作用的丝/苏氨酸蛋白激酶,包括三个成员:Aurora A、B、C。Aurora激酶在大多数肿瘤中均高表达,其异常调控与肿瘤的发生发展密切相关。近年来,Aurora激酶抑制剂作为抗肿瘤候选药物受到广泛的关注,已有一些进入临床试验,且表现出良好的抗肿瘤活性。本文围绕Aurora家族的三个成员,讨论了其在细胞有丝分裂过程中的生物学功能、与肿瘤发生发展的关系及其抑制剂的研究进展,指出其作为抗肿瘤药物靶点的潜在价值。 Aurora kinases, which are involved in the regulation of cell cycle, belong to serine/threonine subclass ofkinases. The three mammalian members, Aurora A, B and C, are strongly expressed in a broad range of cancer types and their aberrant regulations are involved in tumorigenesis. Recently, Aurora kinase inhibitors as antitumor drugs have been developed and a number of these novel agents are currently being studied in phase I and II clinical trials exhibiting a promising clinical efficacy. In this review, we discuss Aurora kinases＇ biological function in mitosis events,involvement in tumorigenesis and the development of their inhibitors and indicate Aurora kinases as potential anticancer targets.
作者 唐帅 李静 耿美玉
机构地区 中国海洋大学医药学院
出处 《现代生物医学进展》 CAS 2009年第11期2175-2178,2143,共5页 Progress in Modern Biomedicine
基金 国家高技术研究发展计划(863计划)资助项目(2007AA09Z405) 国家重点基础研究发展计划(973计划)资助项目(2003CB716400)
关键词 AURORA激酶 抗肿瘤药物 有丝分裂 Aurora kinases Antitumordrugs Mitosis
分类号 Q55 [生物学—生物化学] Q78
  • 相关文献

参考文献42

  • 1Mountzios G, Terpos E, Dimopoulos MA, et al. Aurora kinases as targets for cancer therapy[J]. Cancer Treat Rev, 2008, 34(2): 175-82 被引量：1
  • 2Gautschi O, Heighway J, Mack PC, et al. Aurora kinases as anticancer drug targets. Clin Cancer Res[J]. 2008, 14(6):1639-1648 被引量：1
  • 3Adams RR, Carmena M, Eamshaw WC. Chromosomal passengers and the (aurora) ABCs of mitosis. Trends Cell Biol[J]. 2001, 11(2):49-54 被引量：1
  • 4Mcgraw TL, Li K, Kao LR, et al. The centrosomin protein is required for centrosome assembly and function during cleavage in Drosophila[J]. Development, 1999, 126 (13):2829-2839 被引量：1
  • 5Lee MJ, Gergely F, Jeffers K, et al. Msps/XMAP215 interacts with the centrosomal protein D-TACC to regulate microtubule behaviour [J]. Nat Cell Biol, 2001,3 (7):643-649 被引量：1
  • 6Kemp CA, Kopish KR, Zipperlcn P, et al. Centrosome maturation and duplication in C. elcgans require the coiled-coil protein SPD-2 [J]. Dev Cell, 2004, 6 (4):511-523 被引量：1
  • 7Harmak E, Kirkham M, Hyman AA, et al. Aurora-A kinase is required for eentrosome maturation in Caenorhabditis elegans [J]. J Cell Biol, 2001, 155(7):1109-1116 被引量：1
  • 8Marumoto T, Honda S, Hara T, et al. Aurora-A kinase maintains the fidelity of early and late mitotic events in HeLa ceils [J]. J Biol Chem, 2003, 278(51 ):51786-51795 被引量：1
  • 9Tsai MY, Wiese C, Cao K, et al. A Ran signalling pathway mediated by the mitotic kinase Aurora A in spindle assembly [J]. Nat Cell Biol, 2003, 5(3):242-248 被引量：1
  • 10Du J, Hannon GJ. Suppression of p160ROCK bypasses cell cycle arrest atier Aurora-A/STK15 depletion [J]. Proc Natl Acad Sci USA, 2004, 101(24):8975-8980 被引量：1

同被引文献43

  • 1Li X, Iomini C, Hyink D, et al. PRKX critically regulates endothe- lial cell proliferation, migration, and vascular-like structure forma- tion [ J]. Dev Biol,2011,356 ( 2 ) :475 - 485. 被引量：1
  • 2Klink A, Schiebel K, Winkelmann M, et al. The human protein ki- nase gene PKX1 on Xp22.3 displays Xp/Yp homology and is asite of chromosomal instability [ J ]. Hum Mol Genet, 1995,4 (5) :869 -878. 被引量：1
  • 3Zimmermann B, Chiorini JA, Ma Y ,et aL PrKX is a novel catalyt- ic subunit of the cAMP-dependent protein kinase regulated by the regulatory subunit type I [ J]. J Biol Chem, 1999,274 (9): 5370 - 5378. 被引量：1
  • 4Li X, Li HP, Amsler K, et al. PRKX, a phylogenetically and func- tionally distinct cAMP-dependent protein kinase, activates renal epithelial cell migration and morphogenesis [ J ]. Proc Natl Acad Sci USA ,2002,99 ( 14 ) :9260 - 9265. 被引量：1
  • 5Semizarov D, Glesne D, Laouar A,et al. A lineage-specific protein kinase crucial for myeloid maturation [ J ]. Proc Natl Acad Sci USA, 1998,95 (26) : 15412 - 15417. 被引量：1
  • 6Junttila I, Bourette RP, Rohrschneider LR, et al. M-CSF induced differentiation of myeloid precursor cells involves activation of PKC-deha and expression of Pkare [ J]. J Leukoc Biol,2003,73(2):281 -288. 被引量：1
  • 7Li W, Yu ZX, Kotin RM. Profiles of PrKX expression in develop- mental mouse embryo and human tissues [J]. J Histochem Cyto- chem,2005,53 (8) : 1003 - 1009. 被引量：1
  • 8Di Pasquale G, Stacey SN. Adeno-associated virus Rep78 protein interacts with protein kinase A and its homolog PRKX and inhib- its CREB-dependent transcriptional activation [ J]. J Virol, 1998, 72(10) :7916 -7925. 被引量：1
  • 9Bender C, Ullrich A. PRKX, qTBK2 and RSK4 expression causes sunitinib resistance in kidney carcinoma-and melanoma-cell lines [J]. Int J Cancer,2012,131 (2) :F45 -55. 被引量：1
  • 10Bischoff R,Anderson L,Zhu Y. A homologue of Drosophila Aurora kinase is oncogenic and amplified in human colorectal cancers[J].EMBO Journal,1998,(11):3052-3065.doi:10.1093/emboj/17.11.3052. 被引量：1

引证文献3

现代生物医学进展
2009年 第11期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部