摘要
以豚鼠为实验对象,以外毛细胞缺失率、琥珀酸脱氢酶(SDH)活性和皮层听区诱发电位反应阈为指标,观察高压氧对不同程度声损伤的预防和治疗效 果。结果表明,高压氧具有预防内耳声损伤的作用,可以减少毛细胞缺失,保护SDH,降低暂时性阈移(TTS),使永久性阈移(PTS)转变为TTS,或使PTS降低10dB以上。高压氧治疗也有一定的作用,可以减少毛细胞缺失,保护SDH,但未能改善皮层听区诱发反应阈。2ATA的高压空气对内耳声损伤无预防或治疗作用。
The effects of hyperbaric oxygen (HBO) before and after sound exposure on the hair cell loss rate, the succinic dehydrogenase (SDH) activity, and the cortical evoked potental threshold in guinea pigs were observed. After exposure, in the HBO preventive groups of different exposure intensities, the hair cell losses were less significant, the SDH activities were protected, the temporal threshold shift (TTS) was reduced or the persistent threshold shift (PTS) was turned to TTS, or the PTS was reduced Over 10dB. The therapeutic effect of HBO could also be seen from the rate of hair cell losses and the degree of SDH aetivity reductions among the groups. But the mean hearing of animals was not improved in the therapeufic group. The machanism is still unknown. 2ATA hyperbaric air was not effective to prevent or to treat the acoustic trauma.
出处
《解放军预防医学杂志》
CAS
北大核心
1990年第1期12-16,17,共6页
Journal of Preventive Medicine of Chinese People's Liberation Army
关键词
高压氧
声损伤
内耳
豚鼠
sound-induced auditory damage, hyperbaric oxygen, guinea pigs
