摘要
以γ(δ)-内酯为原料,N-溴代丁二酰亚胺(NBS)为氧化剂,合成了具有不同碳链长度的4(5)-氧代羧酸,其结构经NMR和MS表征。考察了NBS用量对产率的影响和反应温度对反应时间的影响。较适宜的反应条件为γ(δ)-内酯5mmol,NBS6.75mmol,于40℃反应1.5h～3.5h,产率53%～97%。
4 （5）-Oxocarboxylic acids were synthesized from γ（δ）-lactones using/V-bmmosuccmlmlcle （NBS） as an oxidant. The structures were characterized by NMR and MS. The effect of NBS amount on the yield and the effect of reaction temperature on the reaction time were investigated. The appropriate reaction conditions at 40 ℃ for 1.5 h - 3.5 h were as follows ： 5 mmol of γ（δ） -lactone and 6.75 mmol of NBS. The yields were 53% -97% under the reaction conditios.
出处
《合成化学》
CAS
CSCD
北大核心
2009年第3期373-376,共4页
Chinese Journal of Synthetic Chemistry
