摘要
目的:评价IF方案在晚期胃癌治疗中的有效性及安全性。方法:21例晚期胃癌患者,以伊立替康80mg/m2静脉滴注半小时,随后亚叶酸500mg/m2静脉滴注2小时,接着开始持续静脉滴注氟脲嘧啶2000mg/m222个小时,每周1次,连用6周,休息1周后重复。结果:19例可评价患者中,没有CR病例,PR7例(36.8%),PR+SD78.9%。中位生存期10月。不良反应以血液学不良为主,多为I-Ⅱ度(87.0%)。结论:IF方案对晚期胃癌有一定疗效,不良反应可以耐受。
Objective： To evaluate the efficacy and toxicity of IF regimen （irinotecan combined with 5 - fluoroureil） in the treatmeant of advanced gastric cancer. Methods：Twenty -one patients with advanced gastric cancer, were treated with IF regimen （ CPT - 11 80 mg/m2 iv as 30 - min infusion, followed by CF 500 mg/m2 iv over 2h, followed by 5 -FU 2000 mg/m2 iv over 22h, weekly for 6 weeks）. Results：Twenty -one patients were treated with IF regimen,nineteen of them was evaluated. The overall response rate was 78.9% ,no complete response was observed, and seven cases partieal response（63.8% ）. Median survival was 10 months. Most of toxicities was grade Ⅰ-Ⅱ （87.0%）. Conclusion：IF regimen is effective and well tolerable chemotherapy for advanced gastric cancer.
出处
《现代肿瘤医学》
CAS
2009年第6期1136-1137,共2页
Journal of Modern Oncology
关键词
胃癌
伊立替康
氟尿嘧啶
化学疗法
gastric cancer
irinoteean
5 - fluorourcil
chemotherapy
